{"title":"Gut IgA: Never fear, the super inducers are here.","authors":"Pablo Canales-Herrerias, Andrea Cerutti","doi":"10.1016/j.chom.2023.09.004","DOIUrl":null,"url":null,"abstract":"<p><p>In this issue of Cell Host & Microbe, Zhang et al. show that long-term oral administration of a pectin-derived prebiotic broadly enhanced IgA responses to commensals in the small intestine. This effect required T cells and involved Lachnospiraceae A2, suggesting that a few symbionts promote IgA responses to many commensals.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"31 10","pages":"1595-1597"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell host & microbe","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.chom.2023.09.004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
In this issue of Cell Host & Microbe, Zhang et al. show that long-term oral administration of a pectin-derived prebiotic broadly enhanced IgA responses to commensals in the small intestine. This effect required T cells and involved Lachnospiraceae A2, suggesting that a few symbionts promote IgA responses to many commensals.
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