{"title":"Delving into the adytum of the IL-17 defense pathway.","authors":"George Hajishengallis","doi":"10.1016/j.chom.2023.08.021","DOIUrl":null,"url":null,"abstract":"<p><p>Multiple transcription factors are activated in the IL-17 signaling pathway that mediates anti-fungal immunity, although many of them are redundant for protective immunity despite being essential in driving IL-17-mediated autoimmunity. In this issue, Gaffen and colleagues unveil the IκBζ protein as an indispensable transcription factor in IL-17-activated anti-fungal defense.</p>","PeriodicalId":93926,"journal":{"name":"Cell host & microbe","volume":"31 10","pages":"1599-1601"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell host & microbe","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.chom.2023.08.021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Multiple transcription factors are activated in the IL-17 signaling pathway that mediates anti-fungal immunity, although many of them are redundant for protective immunity despite being essential in driving IL-17-mediated autoimmunity. In this issue, Gaffen and colleagues unveil the IκBζ protein as an indispensable transcription factor in IL-17-activated anti-fungal defense.
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