Early-onset schizophrenia: studying the links between cognitive and clinical dimensions.

IF 1.5 4区医学 Q3 PSYCHIATRY

Cognitive Neuropsychiatry Pub Date : 2023-09-01 Epub Date: 2023-11-05 DOI:10.1080/13546805.2023.2266871

Emmanuelle Dor-Nedonsel, Arnaud Fernandez, Marie-Line Menard, Valeria Manera, Gaëlle Laure, Susanne Thümmler, Florence Askenazy

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引用次数: 0

Abstract

Background: Early-onset schizophrenia (EOS), a rare and severe chronic psychiatric condition, is defined by an onset of schizophrenia symptoms before the age of 18. Core symptoms also include cognitive impairments. However, little is known about links between psychiatric symptoms of EOS and cognitive abilities.

Objective: To explore the clinical and neurocognitive profiles of EOS patients and their links.

Method: EOS patients have been phenotyped using standardised psychiatric assessments for DSM-5 diagnoses (K-SADS-PL) and for symptoms (PANSS and SANS), together with neurocognitive evaluations.

Results: The EOS sample (n = 27, 12.4 +/-3.2 years) presented hallucinations (83%), negative symptoms (70%) and delusion (59%). 81% of patients presented comorbidities such as anxiety disorders (33%), autism spectrum disorder (26%) and attention-deficit hyperactivity disorder (26%). Patients presented borderline intellectual deficiency (total IQ = 72.5 +/-4.7), with low performances in working memory subtest. We highlight a positive correlation between the IQ and intensity of positive symptoms (PANSS) and between the IQ and a first treatment being administered at an older age. We also highlight a negative correlation between the IQ and attention items of SANS.

Conclusion: Cognitive skills are correlated with symptom intensity in EOS patients. An older age of onset seems to be a protective factor for cognitive development.

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早发性精神分裂症：研究认知和临床维度之间的联系。

背景：早发性精神分裂症（EOS）是一种罕见且严重的慢性精神病，其定义是在18岁前出现精神分裂症症状。核心症状还包括认知障碍。然而，人们对EOS的精神症状和认知能力之间的联系知之甚少。目的：探讨EOS患者的临床和神经认知特征及其联系。方法：使用DSM-5诊断（K-SADS-PL）和症状（PANSS和SANS）的标准化精神病评估以及神经认知评估对EOS患者进行表型分析。结果：EOS样本（n=27，12.4+/-3.2岁）出现幻觉（83%）、阴性症状（70%）和妄想（59%）。81%的患者患有焦虑症（33%）、自闭症谱系障碍（26%）和注意力缺陷多动障碍（26%。患者表现为临界智力缺陷（总智商=72.5+/-4.7），工作记忆亚测验表现较低。我们强调了智商与阳性症状强度（PANSS）之间的正相关关系，以及智商与老年人首次接受治疗之间的正相关性。我们还强调了SANS的IQ和注意力项目之间的负相关。结论：EOS患者的认知技能与症状强度相关。发病年龄较大似乎是认知发展的一个保护因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cognitive Neuropsychiatry PSYCHIATRY-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

>12 weeks

期刊介绍： Cognitive Neuropsychiatry (CNP) publishes high quality empirical and theoretical papers in the multi-disciplinary field of cognitive neuropsychiatry. Specifically the journal promotes the study of cognitive processes underlying psychological and behavioural abnormalities, including psychotic symptoms, with and without organic brain disease. Since 1996, CNP has published original papers, short reports, case studies and theoretical and empirical reviews in fields of clinical and cognitive neuropsychiatry, which have a bearing on the understanding of normal cognitive processes. Relevant research from cognitive neuroscience, cognitive neuropsychology and clinical populations will also be considered. There are no page charges and we are able to offer free color printing where color is necessary.