Integrative neurocircuits that control metabolism and food intake

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2023-09-29 DOI:10.1126/science.abl7398

Jens C. Brüning, Henning Fenselau

引用次数: 0

Abstract

Systemic metabolism has to be constantly adjusted to the variance of food intake and even be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates multiple homeostatic signals with numerous cues that predict future deviations in energy supply. Recently, our understanding of the neural pathways underlying these regulatory principles—as well as their convergence in the hypothalamus as the key coordinator of food intake, energy expenditure, and glucose metabolism—have been revealed. These advances have changed our view of brain-dependent control of metabolic physiology. In this Review, we discuss new concepts about how alterations in these pathways contribute to the development of prevalent metabolic diseases such as obesity and type 2 diabetes mellitus and how this emerging knowledge may provide new targets for their treatment.

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控制新陈代谢和食物摄入的综合神经回路。

系统代谢必须不断调整以适应食物摄入的变化，甚至为营养供应的预期变化做好准备。因此，大脑将多种稳态信号与预测未来能量供应偏差的众多线索相结合。最近，我们对这些调节原理背后的神经通路的理解，以及它们在下丘脑中的融合，下丘脑是食物摄入、能量消耗和葡萄糖代谢的关键协调器，已经得到了揭示。这些进展改变了我们对大脑依赖性代谢生理控制的看法。在这篇综述中，我们讨论了这些途径的改变如何导致肥胖和2型糖尿病等流行代谢性疾病的发展的新概念，以及这些新兴知识如何为其治疗提供新的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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