Clinical usefulness of phase angle as an indicator of muscle wasting and malnutrition in inpatients with cardiovascular diseases.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Jun Yokomachi, Taira Fukuda, Yuta Mizushima, Naohiro Nozawa, Hayato Ishizaka, Kazuhisa Matsumoto, Takahiro Kambe, Shohta Inoue, Kaori Nishikawa, Yohei Toyama, Reiko Takahashi, Tomoe Arakawa, Hiroshi Yagi, Suomi Yamaguchi, Yuusuke Ugata, Fumitaka Nakamura, Masashi Sakuma, Shichiro Abe, Hideo Fujita, Takashi Mizushima, Shigeru Toyoda, Toshiaki Nakajima
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引用次数: 0

Abstract

Background and Objectives: Extracellular water is increased in patients with edema, such as those with chronic heart failure, and it is difficult to assess skeletal muscle mass with the skeletal muscle mass index when extracellular water is high. We investigated the relationship between phase angle and physical function, nutritional indices, and sarcopenia in patients with cardiovascular diseases, including chronic heart failure. Methods and Study Design: In 590 patients with cardiovascular diseases (372 men), handgrip strength, gait speed, and anterior mid-thigh muscle thickness by ultrasound were measured, and the skeletal muscle mass index, phase angle, and the extracellular water: total body water ratio were measured with a bioelectrical impedance analyzer, and presence of sarcopenia was evaluated. Results: Phase angle, but not the skeletal muscle mass index, was correlated with serum albumin (r = 0.377, p < 0.001) and hemoglobin values in women. Multivariate regression analysis showed that at the extracellular water: total body water ratio below 0.4, both phase angle and skeletal muscle mass index were independent determinants of handgrip strength and log mid-thigh muscle thickness in men, after adjustment for age and presence of chronic heart failure. In contrast, for the ratio of 0.4 or greater, after adjustment for age and presence of chronic heart failure, phase angle was a stronger independent determinant of handgrip strength and log mid-thigh muscle thickness than the skeletal muscle mass index in men. Conclusions: Phase angle is a good marker of muscle wasting and malnutrition in patients with cardiovascular disease, including chronic heart failure.

相位角作为心血管疾病住院患者肌肉萎缩和营养不良指标的临床实用性。
背景和目的:水肿患者(如慢性心力衰竭患者)的细胞外水分增加,当细胞外水分高时,很难用骨骼肌质量指数评估骨骼肌质量。我们研究了包括慢性心力衰竭在内的心血管疾病患者的相位角与身体功能、营养指数和少肌症之间的关系。方法和研究设计:在590例心血管疾病患者(372名男性)中,通过超声测量握力、步态速度和股中前肌厚度,并用生物电阻抗分析仪测量骨骼肌质量指数、相位角和细胞外水与全身水的比,评估少肌症的存在。结果:相位角与女性血清白蛋白(r=0.377,p<0.001)和血红蛋白值相关,但与骨骼肌质量指数无关。多元回归分析显示,在校正了年龄和慢性心力衰竭的存在后,当细胞外水与全身水的比例低于0.4时,相位角和骨骼肌质量指数都是男性握力和股中肌对数厚度的独立决定因素。相反,对于0.4或更大的比率,在调整了年龄和慢性心力衰竭的存在后,相位角是男性握力和股中肌厚度的一个更强的独立决定因素,而不是骨骼肌质量指数。结论:相位角是心血管疾病(包括慢性心力衰竭)患者肌肉萎缩和营养不良的良好标志。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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