Associations between LMO1 gene polymorphisms and central nervous system tumor susceptibility.

IF 1.9 4区 医学 Q2 PEDIATRICS
Pediatric Investigation Pub Date : 2021-08-21 eCollection Date: 2021-12-01 DOI:10.1002/ped4.12286
Huiran Lin, Huitong Chen, Ao Lin, Xiaoping Liu, Xiaokai Huang, Jingying Zhou, Li Yuan, Zhenjian Zhuo
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引用次数: 0

Abstract

Importance: LIM domain only 1 (LMO1) gene polymorphisms were previously found to be implicated in the risk of several cancers. No available studies were performed regarding the predisposing effect of LMO1 gene single nucleotide polymorphisms (SNPs) on central nervous system (CNS) tumor risk.

Objective: We aimed to determine whether the LMO1 gene SNPs were associated with the risk of CNS tumor by applying a case-control study with 191 cases and 248 controls in China.

Methods: The contributions of LMO1 gene SNPs to the risk of CNS tumor was evaluated by multinomial logistic regression.

Results: Based on the calculations of odds ratio (OR) and 95% confidence interval (CI), we failed to detect a significant relationship between each LMO1 gene SNP (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and CNS tumor risk, respectively. A negative association was also found in the combined effects on these five SNPs and CNS tumor risk. The stratification analysis further demonstrated the individuals with rs204938 AG/GG genotype confer to increased risk of CNS tumor compared with those with an AA genotype in males (OR: 1.74, 95% CI: 1.01-2.98, P = 0.046).

Interpretation: We concluded that LMO1 gene SNPs may not strong enough to influence the risk of CNS tumor in Chinese children. More studies are required to verify this association.

Abstract Image

LMO1 基因多态性与中枢神经系统肿瘤易感性之间的关系
重要性:以前曾发现 LIM domain only 1(LMO1)基因多态性与多种癌症的风险有关。目前还没有关于 LMO1 基因单核苷酸多态性(SNPs)对中枢神经系统(CNS)肿瘤风险的易感性影响的研究:目的:通过对中国191例病例和248例对照进行病例对照研究,确定LMO1基因SNPs是否与中枢神经系统肿瘤风险相关:方法:通过多项式逻辑回归评估LMO1基因SNPs对中枢神经系统肿瘤风险的贡献:结果:通过计算几率比(OR)和95%置信区间(CI),我们未能发现LMO1基因各SNP(rs110419 A>G、rs4758051 G>A、rs10840002 A>G、rs204938 A>G和rs2168101 G>T)分别与中枢神经系统肿瘤风险之间存在显著关系。在这五个 SNPs 与中枢神经系统肿瘤风险的联合效应中也发现了负相关。分层分析进一步表明,在男性中,rs204938 AG/GG 基因型的个体比 AA 基因型的个体患中枢神经系统肿瘤的风险更高(OR:1.74,95% CI:1.01-2.98,P = 0.046):我们的结论是,LMO1 基因 SNPs 可能不足以影响中国儿童罹患中枢神经系统肿瘤的风险。我们认为,LMO1 基因 SNPs 对中国儿童中枢神经系统肿瘤风险的影响可能还不够大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pediatric Investigation
Pediatric Investigation Medicine-Pediatrics, Perinatology and Child Health
CiteScore
3.30
自引率
0.00%
发文量
176
审稿时长
12 weeks
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