Neural mechanisms of prospection in individuals with schizotypal traits, autistic traits, or depressive symptoms.

IF 4.6 1区心理学 Q1 Medicine

Journal of abnormal psychology Pub Date : 2021-11-01 DOI:10.1037/abn0000709

Rui-Ting Zhang, Zhuo-Ya Yang, Jia Huang, Yong-Ming Wang, Han-Yu Zhou, Yi Wang, Simon S Y Lui, Eric F C Cheung, Raymond C K Chan

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引用次数: 3

Abstract

Prospection refers to the ability to mentally construct future events, which is closely related to motivation and anhedonia. The neural underpinning of impaired prospection in psychiatric populations remains unclear. We recruited 34 individuals with autistic traits (AT), 27 individuals with schizotypal traits (ST), 31 individuals with depressive symptoms (DS), and 35 controls. Participants completed a prospection task while undergoing functional Magnetic Resonance Imaging (MRI). We found that regions of the "default mode network" including the medial frontal gyrus, the posterior cingulate cortex, the precuneus and the parahippocampus were activated; and regions of the "task-positive network" including the inferior parietal lobe, the inferior frontal gyrus and the precentral gyrus were deactivated during prospection in controls. Compared with controls, AT, ST, and DS showed comparable behavioral performance on prospection. However, reduced activation in anterior cingulate cortex and frontal gyrus was found in AT individuals relative to controls during prospection. ST individuals showed hyperactivation in the caudate relative to controls when processing positive emotion, while DS individuals and controls showed similar neural responses during prospection. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

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具有分裂型特征、自闭症特征或抑郁症状个体前景的神经机制

预期是指在心理上构建未来事件的能力，它与动机和快感缺乏症密切相关。精神科人群前景受损的神经基础仍不清楚。我们招募了34名具有自闭症特征(AT)的个体，27名具有分裂型特征(ST)的个体，31名具有抑郁症状(DS)的个体和35名对照组。参与者在接受功能性磁共振成像(MRI)的同时完成了一项前瞻性任务。我们发现，包括内侧额回、后扣带皮层、楔前叶和副海马体在内的“默认模式网络”区域被激活;而在对照组中，包括顶叶下叶、额下回和中央前回在内的“任务积极网络”区域在展望期间被停用。与对照组相比，AT、ST和DS在前景方面表现出相当的行为表现。然而，在前瞻性研究中，与对照组相比，AT个体的前扣带皮层和额回的激活减少。ST组在处理积极情绪时尾状核相对于控制组表现出过度激活，而DS组和控制组在展望期表现出相似的神经反应。(PsycInfo Database Record (c) 2021 APA，版权所有)。

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来源期刊

Journal of abnormal psychology Multiple-

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期刊介绍： The Journal of Abnormal Psychology® publishes articles on basic research and theory in the broad field of abnormal behavior, its determinants, and its correlates. The following general topics fall within its area of major focus: - psychopathology—its etiology, development, symptomatology, and course; - normal processes in abnormal individuals; - pathological or atypical features of the behavior of normal persons; - experimental studies, with human or animal subjects, relating to disordered emotional behavior or pathology; - sociocultural effects on pathological processes, including the influence of gender and ethnicity; and - tests of hypotheses from psychological theories that relate to abnormal behavior.