Methionine as a double-edged sword in health and disease: Current perspective and future challenges

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2021-12-01 DOI:10.1016/j.arr.2021.101500

Umashanker Navik , Vaibhav G. Sheth , Amit Khurana , Snehal Sainath Jawalekar , Prince Allawadhi , Ravinder Reddy Gaddam , Jasvinder Singh Bhatti , Kulbhushan Tikoo

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引用次数: 16

Abstract

Methionine is one of the essential amino acids and plays a vital role in various cellular processes. Reports advocate that methionine restriction and supplementation provide promising outcomes, and its regulation is critical for maintaining a healthy life. Dietary methionine restriction in houseflies and rodents has been proven to extend lifespan. Contrary to these findings, long-term dietary restriction of methionine leads to adverse events such as bone-related disorders, stunted growth, and hyperhomocysteinemia. Conversely, dietary supplementation of methionine improves hepatic steatosis, insulin resistance, inflammation, fibrosis, and bone health. However, a high level of methionine intake shows adverse effects such as hyperhomocysteinemia, reduced body weight, and increased cholesterol levels. Therefore, dietary methionine in a safe dose could have medicinal values. Hence, this review is aimed to provide a snapshot of the dietary role and regulation of methionine in the modulation of health and age-related diseases.

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蛋氨酸作为健康和疾病的双刃剑:当前的观点和未来的挑战

蛋氨酸是人体必需氨基酸之一，在各种细胞过程中起着至关重要的作用。报告主张蛋氨酸限制和补充提供了有希望的结果，它的调节是维持健康生活的关键。家蝇和啮齿动物饮食中限制蛋氨酸已被证明可以延长寿命。与这些发现相反，长期限制蛋氨酸的饮食会导致不良事件，如骨骼相关疾病、生长发育迟缓和高同型半胱氨酸血症。相反，膳食补充蛋氨酸可改善肝脂肪变性、胰岛素抵抗、炎症、纤维化和骨骼健康。然而，高水平的蛋氨酸摄入会产生副作用，如高同型半胱氨酸血症、体重减轻和胆固醇水平升高。因此，安全剂量的膳食蛋氨酸可能具有药用价值。因此，本综述旨在提供蛋氨酸在调节健康和年龄相关疾病中的膳食作用和调节的快照。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.