Universal scanning-free initiation of eukaryote protein translation-a new normal.

Q2 Biochemistry, Genetics and Molecular Biology

Biomolecular Concepts Pub Date : 2021-09-08 DOI:10.1515/bmc-2021-0014

Saranya Auparakkitanon, Prapon Wilairat

引用次数: 0

Abstract

A unique feature of eukaryote initiation of protein translation is a so-called scanning of 5'-untranslated region (5'-UTR) by a ribosome initiation complex to enable bound Met-tRNA_i access to the initiation codon located further downstream. Here, we propose a universal scanning-free translation initiation model that is independent of 5'-UTR length and applicable to both 5'-m⁷G (capped) and uncapped mRNAs.

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真核生物蛋白翻译的普遍免扫描起始——新常态。

真核生物启动蛋白质翻译的一个独特特征是核糖体启动复合物扫描5'-非翻译区(5'-UTR)，使结合的Met-tRNAi能够进入位于下游的启动密码子。在这里，我们提出了一种独立于5'-UTR长度的通用无扫描翻译起始模型，适用于5'-m7G(带帽)和未带帽的mrna。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecular Concepts Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： BioMolecular Concepts is a peer-reviewed open access journal fostering the integration of different fields of biomolecular research. The journal aims to provide expert summaries from prominent researchers, and conclusive extensions of research data leading to new and original, testable hypotheses. Aspects of research that can promote related fields, and lead to novel insight into biological mechanisms or potential medical applications are of special interest. Original research articles reporting new data of broad significance are also welcome. Topics: -cellular and molecular biology- genetics and epigenetics- biochemistry- structural biology- neurosciences- developmental biology- molecular medicine- pharmacology- microbiology- plant biology and biotechnology.