Role of Proopiomelanocortin in Preventing Miscarriage.

IF 0.2 4区医学 Q4 Medicine

生殖医学杂志 Pub Date : 2017-03-01

Kemal Ozbilgin, Burcu Kahraman, Coşkun Atay, Seda Vatansever, Elgin T Uluer, Tayfun Özçakır

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引用次数: 0

Abstract

Objective: To compare the distribution of proopiomelanocortin (POMC) in decidua and placenta samples from missed abortion and voluntary termination cases in order to research the effects in the etiology of missed abortion.

Study design: Decidual materials were collected from patients who were diagnosed with missed abortion (n=19) and legal voluntary termination cases (n=15) under 10 gestational weeks. Materials were divided into 2 groups for examination. For all samples, POMC primary antibody was performed by immunohistochemical staining. The number of stained cells was calculated by using the H-score technique.

Results: In the missed abortion group the mean age was 28.7 (18–41), and in the control group the mean age was 27.5 (21–37). POMC immunoreactivity was determined to be lower in the parenchyma and placenta of the missed abortion group than those of the control group. POMC immunoreactivities were found to be higher in both the syncytiotrophoblast and cytotrophoblast cells of the missed abortion group than those of the control group (p<0.005).

Conclusion: POMC has become a paradigmatic polypeptide precursor and has a role in the parturition process. Local production of POMC in placenta and decidua may influence pregnancy and may have a role in missed abortion pathogenesis.

本刊更多论文

促肾上腺素在预防流产中的作用。

目的:比较自然流产和自然流产患者蜕膜和胎盘标本中propropiomanocortin (POMC)的分布，探讨其对自然流产病因的影响。研究设计:收集10孕周以下被诊断为漏产的患者(n=19)和合法自愿终止妊娠的患者(n=15)的个体资料。将材料分为两组进行检查。对所有样品进行POMC一抗免疫组织化学染色。H-score法计算染色细胞数。结果:稽留流产组平均年龄28.7岁(18 ~ 41岁)，对照组平均年龄27.5岁(21 ~ 37岁)。结果显示，漏产组的实质组织和胎盘组织POMC免疫反应性明显低于对照组。结果发现，与对照组相比，漏产组的合体滋养细胞和细胞滋养细胞中POMC的免疫反应活性更高(p结论:POMC已成为一种聚合多肽前体，并在分娩过程中发挥作用。胎盘和蜕膜中POMC的局部产生可能影响妊娠，并可能在漏产的发病机制中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生殖医学杂志医学-妇产科学

自引率

0.00%

发文量

6427

审稿时长

6-12 weeks

期刊介绍： The Journal of Reproductive Medicine® has been the essential tool of Obstetricians and Gynecologists since 1968. As a highly regarded professional journal and the official periodical of six medical associations, JRM® brings timely and relevant information on the latest procedures and advances in the field of reproductive medicine. Published bimonthly, JRM® contains peer-reviewed articles and case reports submitted by top specialists. Common topics include research, clinical practice, and case reports related to general obstetrics and gynecology, infertility, female cancers, gynecologic surgery, contraception, and medical education.