Clinical probe utilizing surface enhanced Raman scattering.

IF 1.5 4区 工程技术 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC
Jeonghwan Kim, Dooyoung Hah, Theda Daniels-Race, Martin Feldman
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引用次数: 8

Abstract

Conventional Raman scattering is a well-known technique for detecting and identifying complex molecular samples. In surface enhanced Raman scattering, a nanorough metallic surface close to the sample enormously enhances the Raman signal. In previous work, the metallic surface was a thin layer of gold deposited on a rough transparent epoxy substrate. The advantage of the clear substrate was that the Raman signal could be obtained by passing light through the substrate, on to opaque samples simply placed against its surface. In this work, a commercially available Raman spectrometer was coupled to a distant probe. Raman signals were obtained from the surface, and from the interior, of a solid specimen located more than 1 m away from the spectrometer. The practical advantage of this arrangement is that it opens up surface enhanced Raman spectrometry to a clinical environment, with a patient simply sitting or lying near the spectrometer.

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利用表面增强拉曼散射的临床探针。
传统的拉曼散射是一种众所周知的检测和鉴定复杂分子样品的技术。在表面增强拉曼散射中,靠近样品的纳米级金属表面极大地增强了拉曼信号。在以前的工作中,金属表面是一层薄薄的金,沉积在粗糙的透明环氧基板上。透明衬底的优点是,拉曼信号可以通过将光穿过衬底,照射到不透明的样品上而获得。在这项工作中,一个商用拉曼光谱仪与一个遥远的探测器耦合在一起。拉曼信号是从距离光谱仪1米以上的固体样品的表面和内部获得的。这种安排的实际优势在于,它将表面增强拉曼光谱法应用于临床环境,患者只需坐在或躺在光谱仪附近。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
0.00%
发文量
146
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