Structural and magnetic characterization of superparamagnetic iron platinum nanoparticle contrast agents for magnetic resonance imaging.

IF 1.5 4区 工程技术 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC
Robert M Taylor, Dale L Huber, Todd C Monson, Victor Esch, Laurel O Sillerud
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引用次数: 3

Abstract

The authors report the synthesis, from simple salts, and the physical characterization of superparamagnetic iron platinum nanoparticles (SIPPs) suitable for use as contrast agents in magnetic resonance imaging. The properties of these particles were determined by means of transmission electron microscopy (TEM), thermogravimetric analysis, inductively coupled plasma-optical emission spectroscopy (ICP-OES), superconducting quantum interference device (SQUID) magnetometry, and nuclear magnetic resonance relaxivity at 4.7 T. TEM showed that the diameters of the particles ranged from 9.3 to 10 nm, depending on the mole ratio of iron to platinum precursors, and on the concentration of octadecylamine (ODA) used in their preparation. The iron to platinum stoichiometry determined by ICP-OES varied from 1.4:1 to 3.7:1 and was similarly dependent on the initial mole ratios of iron and platinum salts, as well as on the concentration of ODA in the reaction. SQUID magnetometry showed that the SIPPs were superparamagnetic and had magnetic moments that increased with increasing iron content from 62 to 72 A·m2/kg Fe. The measured relaxivities of the SIPPs at 4.7 T were higher than commercially available superparamagnetic iron oxide nanoparticles, suggesting that these particles may be superior contrast agents in T2-weighted magnetic resonance imaging.

磁共振成像用超顺磁性铁铂纳米颗粒造影剂的结构和磁性表征。
作者报道了用简单盐合成适合用作磁共振成像造影剂的超顺磁性铁铂纳米颗粒(SIPPs)及其物理特性。通过透射电子显微镜(TEM)、热重分析、电感耦合等离子体-光学发射光谱(ICP-OES)、超导量子干涉仪(SQUID)磁强计和4.7 t核磁共振弛豫率对这些粒子的性质进行了测定。TEM表明,根据铁与铂前驱体的摩尔比,这些粒子的直径范围为9.3 ~ 10 nm;以及在其制备中使用的十八胺(ODA)的浓度。ICP-OES测定的铁与铂的化学计量在1.4:1到3.7:1之间变化,同样取决于铁和铂盐的初始摩尔比,以及反应中ODA的浓度。SQUID磁强计表明SIPPs具有超顺磁性,磁矩随铁含量的增加而增大,从62 ~ 72 A·m2/kg Fe。SIPPs在4.7 T时的测量弛豫度高于市上可用的超顺磁性氧化铁纳米颗粒,表明这些颗粒可能是t2加权磁共振成像中较好的造影剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
0.00%
发文量
146
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