Lupane-Type Saponins from Leaves of Acanthopanax sessiliflorus and Their Inhibitory Activity on Pancreatic Lipase

IF 6.2 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2005-12-22 DOI:10.1021/jf052047f

Kazuma Yoshizumi, Kaoru Hirano, Hidehiro Ando, Yasuaki Hirai, Yoshiteru Ida, Tomoko Tsuji, Tamotsu Tanaka, Kiyoshi Satouchi, Junji Terao

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引用次数: 99

Abstract

Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novel saponin, 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid 28-O-α-l-rhamnopyranosyl (1→4)-β-d-glucopyranosyl (1→6)-β-d-glucopyranoside, referred to as sessiloside, were isolated from a hot water extract of Acanthopanax sessiliflorus leaves. All of these saponins were lupane-type triterpene triglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract, respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition of the saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibility of application of the lupane-type saponins from A. sessiliflorus leaves to the treatment of obesity is discussed.

Keywords: Lipase inhibitor; Acanthopanax sessiliflorus; lupane-type saponin; chiisanoside; sessiloside; obesity

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无梗五加叶片中豆烷型皂苷及其对胰脂肪酶的抑制活性

从无梗五加叶热水提取液中分离得到了三种已知的皂苷，分别为chiisano苷、11-脱氧异chiisano苷和异chiisano苷，以及一种新的皂苷，即3,4-seco-4(23)、20(29)-狼二烯-3,28-二酸28-O-α-l-rhamnopyranosyl(1→4)-β-d-glucopyranosyl(1→6)-β-d-glucopyranosyl(1→6)-β-d-glucopyranosyl，简称无梗五加苷。这些皂苷均为羽扇烷型三萜甘油三酯，其含量分别为总提取物的4.1、1.0、0.5和0.4% (w/w)。五味子皂苷和chiisanoside在体外抑制胰腺脂肪酶活性，在高脂肪饮食中添加富含皂苷的部分抑制小鼠体重增加。探讨了无梗花叶片羽扇烷型皂苷在肥胖治疗中的应用可能性。关键词:脂肪酶抑制剂;刺五加sessiliflorus;lupane-type皂苷;chiisanoside;sessiloside;肥胖

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.