Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2011-07-01 DOI:10.1126/science.1201043

Daniele Viviani, Alexandre Charlet, Erwin van den Burg, Camille Robinet, Nicolas Hurni, Marios Abatis, Fulvio Magara, Ron Stoop

{"title":"Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala","authors":"Daniele Viviani, Alexandre Charlet, Erwin van den Burg, Camille Robinet, Nicolas Hurni, Marios Abatis, Fulvio Magara, Ron Stoop","doi":"10.1126/science.1201043","DOIUrl":null,"url":null,"abstract":"<div >Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"333 6038","pages":""},"PeriodicalIF":45.8000,"publicationDate":"2011-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1126/science.1201043","citationCount":"334","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science","FirstCategoryId":"103","ListUrlMain":"https://www.science.org/doi/10.1126/science.1201043","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 334

Abstract

Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.

查看原文本刊更多论文

催产素通过中枢杏仁核的不同输出选择性地控制恐惧反应

杏仁核中枢（CeA）向下丘脑和脑干核团的投射可调节恐惧的行为和生理表现，但恐惧反应的这些不同方面是否可分别受到 CeA 的调节尚不清楚。我们结合体外电生理记录和体内相关行为和生理参数监测，对调节恐惧相关冻结或心血管反应的核团的CeA投射进行了荧光逆行追踪。CeA投射来自不同的神经元群，它们具有不同的电生理特征和对催产素的不同反应特性。在体内，催产素可减少恐惧条件反射大鼠的冻结反应，但不影响心血管反应。因此，神经肽能信号可通过不同的神经元回路调节CeA输出，从而单独引导恐惧反应的各个方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

期刊介绍： Science is a leading outlet for scientific news, commentary, and cutting-edge research. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. Science’s authorship is global too, and its articles consistently rank among the world's most cited research. Science serves as a forum for discussion of important issues related to the advancement of science by publishing material on which a consensus has been reached as well as including the presentation of minority or conflicting points of view. Accordingly, all articles published in Science—including editorials, news and comment, and book reviews—are signed and reflect the individual views of the authors and not official points of view adopted by AAAS or the institutions with which the authors are affiliated. Science seeks to publish those papers that are most influential in their fields or across fields and that will significantly advance scientific understanding. Selected papers should present novel and broadly important data, syntheses, or concepts. They should merit recognition by the wider scientific community and general public provided by publication in Science, beyond that provided by specialty journals. Science welcomes submissions from all fields of science and from any source. The editors are committed to the prompt evaluation and publication of submitted papers while upholding high standards that support reproducibility of published research. Science is published weekly; selected papers are published online ahead of print.