An Octacalcium Phosphate Forming Cement.

IF 1.5 4区 工程技术
M Markovic, L C Chow
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引用次数: 21

Abstract

The osteoconductive and possibly osteoinductive characteristics of OCP increased the interest in preparation of bone graft materials that contain OCP in its composition. Calcium phosphate cements (CPCs) were prepared using a mixture of α-tricalcium phosphate (α-TCP) and dicalcium phosphate anhydrous (DCPA), with α-TCP / DCPA molar ratio of 1/1 and distilled water or 0.5 mol / L phosphate aqueous solution (pH = 6.1 ± 0.1) as the cement liquid. Hardening time was (30 ± 1) min for the CPC mixed with water and (5 ± 1) min for the CPC mixed with phosphate solution. Diametral tensile strength (DTS), porosity (P), and phase composition (powder x-ray diffraction) were determined after the hardened specimens had been immersed in a physiological-like solution (PLS) for 1 d, 3 d, and 7 d. In CPC specimens prepared with water, calcium hydroxyapatite (HA) was formed and DTS and P were (9.03 ± 0.48) MPa and (37.05 ± 0.20) vol % after 1 d, respectively, and (9.15 ± 0.45) MPa and (37.24 ± 0.63) vol % after 3 d, respectively. In CPC specimens prepared with phosphate solution OCP and HA were formed and DTS and P were (4.38 ± 0.49) MPa and (41.44 ± 1.25) vol % after 1 d, respectively,(4.38 ± 0.29) MPa and (42.52 ± 2.15) vol % after 3 d, respectively, and (4.30 ± 0.60) MPa and (41.38 ± 1.65) vol % after 7 d, respectively. For each group DTS and P did not change with PLS immersion time. DTS was significantly higher and P was significantly lower for CPCs prepared with water. HA formation slightly increased with immersion time from 40 mass % after 1 d to 50 mass % after 3 d in CPCs prepared with water. OCP + HA formation increased with immersion time from 30 mass % after 1 d to 35 mass % after 3 d and to 45 mass % after 7 d in CPCs prepared with 0.5 mol / L phosphate solution.

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八磷酸钙形成水泥。
OCP的骨导电性和可能的骨诱导特性增加了在其组成中含有OCP的骨移植材料制备的兴趣。以α-磷酸三钙(α-TCP)和无水磷酸二钙(DCPA)为原料,α-TCP / DCPA的摩尔比为1/1,以蒸馏水或0.5 mol / L磷酸水溶液(pH = 6.1±0.1)为水泥液制备磷酸钙水泥(CPCs)。与水混合的CPC硬化时间为(30±1)min,与磷酸盐溶液混合的CPC硬化时间为(5±1)min。径向抗张强度(DTS)、孔隙度(P)和相组成(粉末x射线衍射)测定硬化后标本一直沉浸在physiological-like解决方案(PLS) 1 d、3 d,和7 d。在中国共产党标本准备水,钙羟磷灰石(HA)成立和DTS和P(9.03±0.48)MPa和(37.05±0.20)% 1 d后卷,分别和(9.15±0.45)MPa和(37.24±0.63)%卷3 d后,分别。磷酸溶液制备的CPC标本OCP和HA形成,1d后DTS和P分别为(4.38±0.49)MPa和(41.44±1.25)vol %, 3d后DTS和P分别为(4.38±0.29)MPa和(42.52±2.15)vol %, 7d后分别为(4.30±0.60)MPa和(41.38±1.65)vol %。各组DTS和P均不随PLS浸泡时间变化。经水处理的CPCs的DTS显著升高,P显著降低。羟基磷灰石的形成随着浸泡时间的增加而略有增加,从1 d后的40%质量%增加到3 d后的50%质量%。在0.5 mol / L磷酸溶液中,OCP + HA的形成随浸泡时间的增加而增加,从浸泡1 d后的30质量%增加到浸泡3 d后的35质量%,浸泡7 d后增加到45质量%。
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来源期刊
自引率
33.30%
发文量
10
期刊介绍: The Journal of Research of the National Institute of Standards and Technology is the flagship publication of the National Institute of Standards and Technology. It has been published under various titles and forms since 1904, with its roots as Scientific Papers issued as the Bulletin of the Bureau of Standards. In 1928, the Scientific Papers were combined with Technologic Papers, which reported results of investigations of material and methods of testing. This new publication was titled the Bureau of Standards Journal of Research. The Journal of Research of NIST reports NIST research and development in metrology and related fields of physical science, engineering, applied mathematics, statistics, biotechnology, information technology.
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