Myofibrillar protein-chlorogenic acid complexes ameliorate glucose metabolism via modulating gut microbiota in a type 2 diabetic rat model

IF 8.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2023-05-30 DOI:10.1016/j.foodchem.2022.135195

Zhiwei Zhou , Dan Wang , Xinyi Xu , Jin Dai , Guangjie Lao , Senlin Zhang , Xiaofang Xu , András Dinnyés , Youling Xiong , Qun Sun

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引用次数: 5

Abstract

Growing evidence suggests that polyphenols could mitigate type 2 diabetes mellitus (T2DM). The glucose-regulatory effects of protein-bound polyphenols, however, have been rarely studied. In this study, macrogenomic and metabolomic analyses were applied to investigate the modulation of myofibrillar protein-chlorogenic acid (MP-CGA) complexes on T2DM rats from the gut microbiota perspective. Results showed that MP-CGA improved hyperglycemia and hyperlipidemia, decreased intestinal inflammation, and reduced intestinal barrier injury. MP-CGA reconstructed gut microbiota in T2DM rats, elevating the abundance of probiotics Bacteroides, Akkermansia, and Parabacteroides while suppressing opportunistic pathogens Enterococcus and Staphylococcus. MP-CGA significantly elevated the concentrations of intestinal metabolites like butyric acid that positively regulate T2DM and reduced the secondary bile acids contents. Therefore, MP-CGA modulated the gut microbiota and related metabolites to maintain stable blood glucose in T2DM rats, providing new insights into the application of protein-polyphenol complexes in foods.

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肌原纤维蛋白-绿原酸复合物通过调节2型糖尿病大鼠的肠道微生物群改善葡萄糖代谢

越来越多的证据表明，多酚可以减轻2型糖尿病(T2DM)。然而，蛋白质结合多酚的葡萄糖调节作用很少被研究。本研究采用宏观基因组学和代谢组学分析，从肠道微生物群的角度研究了肌纤维蛋白-绿原酸(MP-CGA)复合物对T2DM大鼠的调节作用。结果显示，MP-CGA可改善高血糖和高脂血症，减轻肠道炎症，减轻肠屏障损伤。MP-CGA重建T2DM大鼠肠道菌群，提高益生菌类拟杆菌、阿克曼氏菌和拟副杆菌的丰度，同时抑制条件致病菌肠球菌和葡萄球菌。MP-CGA显著提高肠道代谢物如正调节T2DM的丁酸浓度，降低次级胆汁酸含量。因此，MP-CGA通过调节肠道菌群及相关代谢物维持T2DM大鼠的血糖稳定，为蛋白-多酚复合物在食品中的应用提供了新的见解。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.