Wireless electrocatalytic closed-loop system for drug-free management of diabesity

IF 47.3 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2026-10-22 DOI:10.1126/science.ady8560

Debasis Maity, Preetam Guha Ray, Peter Buchmann, Ghislaine Charpin-El Hamri, Martin Fussenegger

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Abstract

Lifestyle-related type 2 diabetes and associated obesity (diabesity) affect >2.5 billion people worldwide and impose nearly $3 trillion in annual health care costs. We developed an implantable, wirelessly powered electrocatalytic closed-loop health optimization (ECHO) device containing platinum-decorated gold nanoclusters embedded in graphite felt that enabled selective, electrically tunable oxidation of blood glucose to renally cleared gluconate. In type 2 diabetic mice, wireless, low-power activation (0.75 volts, 10 milliamperes) restored glucose homeostasis within 1 hour, shifted metabolism from glucose to lipid utilization, reduced body weight and triglycerides, and increased circulating free fatty acids and ketone bodies without detectable hypoglycemia or adverse physiological, inflammatory, or behavioral effects during 6 weeks of treatment. Coupling this ECHO device to a commercial continuous glucose monitoring system enabled autonomous, smartphone-controlled, drug-free closed-loop management of experimental diabesity.

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用于糖尿病无药管理的无线电催化闭环系统

与生活方式相关的2型糖尿病和相关肥胖（糖尿病）影响着全球25亿人，每年造成近3万亿美元的医疗保健费用。我们开发了一种可植入的、无线供电的电催化闭环健康优化（ECHO）设备，该设备将铂装饰的金纳米团簇嵌入石墨感觉中，使血糖能够选择性地、电可调地氧化，从而清除葡萄糖酸盐。在2型糖尿病小鼠中，无线、低功率激活（0.75伏，10毫安）在1小时内恢复葡萄糖稳态，将代谢从葡萄糖转化为脂质利用，降低体重和甘油三酯，增加循环游离脂肪酸和酮体，在6周的治疗期间没有检测到低血糖或不良生理、炎症或行为影响。将这种ECHO设备与商业连续血糖监测系统相结合，可以实现自主、智能手机控制、无药物的实验性糖尿病闭环管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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