Fluorinated Microporous Organic Network-Based Cooling-Assisted SPME for Ultra-Trace Determination of Fluorinated Liquid Crystal Monomers

IF 7.3 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2026-10-15 DOI:10.1021/acs.analchem.6c04012

Jiayu Chen,Yehong Han,Fengxia Qiao,Junfa Yin,Dandan Han,Hongyuan Yan

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引用次数: 0

Abstract

Abstract Fluorinated liquid crystal monomers (FLCMs), widely used in electronic displays, have emerged as persistent and bioaccumulative contaminants, yet their ultra-trace determination in complex matrices remains challenging. Herein, a cooling-assisted solid-phase microextraction (CA-SPME) method based on a fluorinated microporous organic network (F-MON) coating, coupled with GC−MS/MS, is developed for ultra-trace determination of FLCMs in environmental water and soil. The F-MON coating, featuring abundant fluorinated active sites and a hierarchical porous structure, provides strong affinity toward FLCMs via synergistic fluorine−fluorine, hydrophobic, and π−π interactions. A self-designed cooling-assisted device establishes a temperature gradient that suppresses analyte desorption and enhances partitioning into the extraction phase. The method exhibits rapid adsorption kinetics and multilayer adsorption behavior. Under optimized conditions, ultralow limits of quantification (0.02−0.26 pg mL−1) and high enrichment factors (6394−15782) are achieved, with excellent linearity (r ≥ 0.9995), good reproducibility (RSDs ≤ 11.5%), and negligible matrix effects (−22.1% to 20.7%). Compared with existing approaches, this method offers reduced sample and solvent consumption, simplified operation, and superior sensitivity. This work provides a robust analytical platform for trace FLCMs and highlights the synergistic potential of fluorinated porous fiber materials and cooling-assisted extraction strategies in advanced sample pretreatment.

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基于氟化微孔有机网络的冷却辅助SPME超痕量测定氟化液晶单体

摘要氟化液晶单体（flcm）广泛应用于电子显示器中，是一种具有持久性和生物蓄积性的污染物，但其在复杂基质中的超痕量测定仍然具有挑战性。本文建立了一种基于氟化微孔有机网络（F-MON）涂层的冷却辅助固相微萃取（CA-SPME）方法，结合气相色谱-质谱联用（GC - MS/MS），用于环境水和土壤中flcm的超痕量测定。F-MON涂层具有丰富的氟化活性位点和分层多孔结构，通过协同氟-氟、疏水和π - π相互作用对flcm具有很强的亲和力。自行设计的冷却辅助装置建立温度梯度，抑制分析物的解吸，并增强分配到萃取相。该方法具有快速吸附动力学和多层吸附特性。优化条件下，定量限极低（0.02 ~ 0.26 pg mL−1），富集因子高（6394 ~ 15782），线性良好（r≥0.9995），重现性好（rsd≤11.5%），基质效应可忽略（- 22.1% ~ 20.7%）。与现有方法相比，该方法减少了样品和溶剂的消耗，操作简单，灵敏度高。这项工作为痕量flcm提供了一个强大的分析平台，并突出了氟化多孔纤维材料和冷却辅助提取策略在高级样品预处理中的协同潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.