A pair of chitosan receptors confer broad-spectrum fungal resistance

IF 47.3 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2026-10-15 DOI:10.1126/science.ady7647

Keyi Huang, Jingni Wu, Yu Cao, Yingying Cao, Zhongji Pu, Aoshen Xu, Wenzhao Wang, Xue Zhou, Ming Li, Min Zhang, Yuhua Wang, Jinbiao Ma, Yulin Du, Qin Wang, Yingqiao Wan, Shangyu Gao, Dacheng Wang, Guangzheng Sun, Qin Gu, Huan Chen, Guosheng Xiong, Heng Yin, Yiwen Deng, Wensheng Zhao, Zhengguang Zhang, Shengben Li, Xiquan Gao, Sun Tae Kim, Gang Li, Baolei Jia, Jijie Chai, Kenichi Tsuda, Zheng Qing Fu, Yiming Wang

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引用次数: 0

Abstract

Chitosan, a major fungal cell wall component, activates plant immunity, yet the underlying perception mechanism remains unknown. In this study, we identified OsFID1, an apoplast-localized DUF26 domain protein, as a chitosan-binding receptor essential for chitosan-triggered immunity. OsFID1 forms a receptor complex with OsFID2, a plasma membrane–localized DUF26 receptor-like kinase, to mediate chitosan sensing and immune activation, requiring OsFID2 phosphorylation for function. The OsFID1-OsFID2 complex confers broad-spectrum resistance to fungal pathogens. OsFID1 homologs are conserved in land plants, which show chitosan-binding activity in both monocots and dicots. Ectopic expression of OsFID1 in wheat and maize enhanced fungal resistance without growth penalty. These findings uncover a conserved receptor complex for direct chitosan sensing, advancing our understanding of plant-fungus interactions and providing a potential strategy for engineering durable fungal resistance crops.

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一对壳聚糖受体赋予真菌广谱抗性

壳聚糖是真菌细胞壁的主要成分，可激活植物免疫，但其潜在的感知机制尚不清楚。在这项研究中，我们发现OsFID1，一个外质体定位的DUF26结构域蛋白，是壳聚糖触发免疫所必需的壳聚糖结合受体。OsFID1与OsFID2（一种质膜定位的DUF26受体样激酶）形成受体复合物，介导壳聚糖感知和免疫激活，需要OsFID2磷酸化才能发挥作用。OsFID1-OsFID2复合物对真菌病原体具有广谱抗性。OsFID1同源物在陆地植物中是保守的，在单子叶和双子叶中都表现出壳聚糖结合活性。OsFID1在小麦和玉米中的异位表达增强了对真菌的抗性，但不影响其生长。这些发现揭示了一种保守的壳聚糖直接感应受体复合物，促进了我们对植物与真菌相互作用的理解，并为设计耐久的抗真菌作物提供了潜在的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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