Post-stroke spasticity: advances in network mechanisms and therapeutics.

IF 3.6 3区医学 Q3 NEUROSCIENCES

Frontiers in Human Neuroscience Pub Date : 2026-09-25 eCollection Date: 2026-01-01 DOI:10.3389/fnhum.2026.1868901

Wei Yao, Yuanbin Yang, Zhiyi Wang, Longyue Yi, Deya Daneva, Zhuangwei Fang, Keyun Gan, Zhiqi Lin

引用次数: 0

Abstract

Spasticity is one of the common complications of stroke, causing serious adverse effects for patients. However, comprehensive descriptions of the PSS network mechanism are currently lacking. This paper expounds on the mechanisms underlying post-stroke spasticity from multiple perspectives, including central nervous system networks, neurotransmitter networks, pain networks, and myofascial networks, as well as the brain-gut axis and brain-muscle axis networks. It summarizes emerging treatment approaches in recent years, providing a reference for clinical treatment and rehabilitation.

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脑卒中后痉挛：网络机制和治疗的进展。

痉挛是脑卒中常见的并发症之一，对患者造成严重的不良反应。然而，目前对PSS网络机制缺乏全面的描述。本文从中枢神经系统网络、神经递质网络、疼痛网络、肌筋膜网络以及脑肠轴和脑肌轴网络等多个角度阐述了脑卒中后痉挛的机制。总结了近年来新兴的治疗方法，为临床治疗和康复提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Human Neuroscience 医学-神经科学

CiteScore

4.70

自引率

6.90%

发文量

830

审稿时长

2-4 weeks

期刊介绍： Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.