A microglial circadian clock sculpts synapses during neurodevelopment.

IF 15.7 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2026-09-22 DOI:10.1016/j.tins.2026.09.002

Annemarie J Carver, Nicole R Zürcher, Evan A Bordt

引用次数: 0

Abstract

In a recent study, Routh and colleagues demonstrated that the circadian clock regulates microglia-directed synaptic refinement during a critical period of neurodevelopment in mice, in a sex-dependent manner. Loss of the major circadian rhythm regulator, Bmal1, in microglia induced a proinflammatory state and excessive pruning of synapses, primarily in adolescent male mice.

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在神经发育过程中，小胶质生物钟雕刻突触。

在最近的一项研究中，Routh和他的同事证明，在小鼠神经发育的关键时期，生物钟以性别依赖的方式调节小胶质细胞导向的突触完善。主要在青春期雄性小鼠中，小胶质细胞中主要昼夜节律调节因子Bmal1的缺失导致了促炎状态和突触的过度修剪。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.