Association Between Extrafoveal Paravascular Retinoschisis and Central Retinal Vessel Trunk Dragging in High Myopia.

IF 5.5 2区医学 Q1 OPHTHALMOLOGY

Investigative ophthalmology & visual science Pub Date : 2026-10-01 DOI:10.1167/iovs.67.12.7

Jost B Jonas, Rahul A Jonas, Ya Xing Wang, Songhomitra Panda-Jonas

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Abstract

Purpose: To assess occurrence and associations of myopic extrafoveal paravascular retinoschisis (EPR).

Methods: Using optical coherence tomographic images of the optic disc and macula, taken in the population-based Beijing Eye Study, we assessed prevalence and associations of parapapillary retinoschisis.

Results: The study included 3336 individuals (3336 eyes) with a mean age of 64.2 ± 9.6 years (range, 50-93) and a mean axial length of 23.4 ± 1.2 mm (range, 20.16-30.88). EPR prevalence (34/3336, 1.0%; 95% confidence interval [CI], 0.6-1.4) increased from 1/3046 (0.03%) to 8/173 (4.6%; 95% CI, 1-8), 4/74 (5.4%; 95% CI, 0-11), 10/25 (40%; 95% CI, 19-61), and 11/18 (61%; 95% CI, 36-86) with axial lengths of ≤25.0 mm, 25.01 to 26.0 mm, 26.01 to 27.0 mm, 27.01 to 28.0 mm, and >28.0 mm, respectively. Higher EPR prevalence was associated (multivariable analysis) with higher prevalence of central retinal vessel trunk dragging (CRVTD) (odds ratio [OR] = 8.81; 95% CI, 3.02-25.7; P < 0.001) and longer axial length (OR = 2.97; 95% CI, 2.27-3.89; P < 0.001; Nagelkerke R2 = 0.55), or alternatively with longer fovea-optic disc center distance (OR = 2.79; 95% CI, 1.55-5.03; P < 0.001). In a nonlinear manner, EPR prevalence increased steeply beyond an axial length of 25.5 mm and a fovea-disc center distance of 5.5 mm. These relationships were complemented by univariate associations between EPR prevalence and temporal retinal vessel straightening, smaller angle kappa, higher myopic macular degeneration stage and prevalence, and larger parapapillary beta zone and gamma zone.

Conclusions: EPR was a common feature in eyes with severe/high axial myopia and was mainly associated with CRVTD and longer axial length or fovea-disc center distance. As a hypothesis, EPR, contrary to myopic foveoschisis, may be due to a stretching of the temporal large retinal vessels in highly myopic eyes, related to the fovea-disc distance elongation.

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高度近视视网膜中央血管干拖曳与凹外血管旁视网膜裂的关系。

目的：探讨近视中央凹外血管旁视网膜裂（EPR）的发生及相关因素。方法：利用以人群为基础的北京眼科研究中拍摄的视盘和黄斑的光学相干层析图像，我们评估了乳头状旁视网膜裂的患病率及其相关性。结果：研究对象3336人（3336只眼），平均年龄64.2±9.6岁（范围50 ~ 93岁），平均眼轴长度23.4±1.2 mm（范围20.16 ~ 30.88岁）。EPR患病率（34/3336,1.0%，95%可信区间[CI]， 0.6-1.4）分别从1/3046（0.03%）增加到8/173 (4.6%,95% CI, 1-8), 4/74 (5.4%, 95% CI, 0-11), 10/25 （40%, 95% CI, 19-61）和11/18 (61%,95% CI, 36-86)，轴向长度分别为≤25.0 mm, 25.01 ~ 26.0 mm, 26.01 ~ 27.0 mm, 27.01 ~ 28.0 mm和bb0 28.0 mm。较高的EPR患病率（多变量分析）与较高的视网膜中央血管干拖（CRVTD）患病率相关（优势比[OR] = 8.81; 95% CI, 3.02-25.7; P < 0.001）和较长的轴长（OR = 2.97; 95% CI, 2.27-3.89; P < 0.001; Nagelkerke R2 = 0.55），或者与较长的中央窝-视盘中心距离相关（OR = 2.79; 95% CI, 1.55-5.03; P < 0.001）。当轴向长度超过25.5 mm和中央凹-椎间盘中心距离超过5.5 mm时，EPR发病率呈非线性增长。EPR患病率与颞视网膜血管矫直、较小的角kappa、较高的近视黄斑变性阶段和患病率以及较大的乳头旁β区和γ区之间的单变量相关性补充了这些关系。结论：EPR是重度/高度轴型近视的共同特征，主要与CRVTD和较长的轴长或中央凹-椎间盘中心距离有关。作为一种假设，EPR，与近视的中央凹裂相反，可能是由于高度近视的眼睛的颞部大视网膜血管的拉伸，与中央凹-椎间盘距离的伸长有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative ophthalmology & visual science 医学-眼科学

CiteScore

6.90

自引率

4.50%

发文量

339

审稿时长

1 months

期刊介绍： Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.