Suppression of microglial MEF2C by α-Synuclein is associated with neuroinflammation in a mouse model of Parkinson's disease and promotes degeneration In Vitro

IF 4.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2026-10-15 Epub Date: 2026-09-29 DOI:10.1016/j.brainresbull.2026.112145

Xiaohuan Liu, Rong Zhou, Cheng Wen, Rulin Geng, Jiehua Su, Zhuoying Lai, Kaixun Huang, Yiqiang Zhan, Danyu Lin, Enxiang Tao

引用次数: 0

Abstract

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α-Synuclein downregulates the expression of microglial MEF2C in Parkinson’ disease.
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MEF2C suppression promotes HMC3 and SH-SY5Y cells’ apoptosis through activating Bax/Bcl-2 pathway.
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Decreased MEF2C drives microglia proinflammatory polarization, with elevated cytokines secretion.
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Nucleolin and nucleophosmin are identified as upstream regulators of α-syn-induced MEF2C suppression.

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α-突触核蛋白抑制小胶质细胞MEF2C与帕金森病小鼠模型的神经炎症相关，并在体外促进变性

•α-Synuclein下调帕金森病小胶质细胞MEF2C的表达。•MEF2C抑制通过激活Bax/Bcl-2通路促进HMC3和SH-SY5Y细胞凋亡。•减少MEF2C驱动小胶质细胞促炎极化，增加细胞因子分泌。•Nucleolin和nucleophosmin被认为是α-syn诱导的MEF2C抑制的上游调节因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.