Mechanistic Insights into Solvent-Dependent Ultrasound-Assisted Extraction of Hemp Phytochemicals: From Decarboxylation to Oil-Based Systems

IF 3 Q2 FOOD SCIENCE & TECHNOLOGY

ACS food science & technology Pub Date : 2026-09-18 Epub Date: 2026-08-25 DOI:10.1021/acsfoodscitech.6c00127

Pinyada Jaroenkunpanit, Juraithip Wungsintaweekul, Pakamas Chetpattananondh

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Abstract

An integrated understanding of how thermal pretreatment and solvent physicochemical properties govern ultrasound-assisted extraction (UAE) of hemp phytochemicals remains limited. This study systematically investigated the effects of decarboxylation and solvent properties on extraction selectivity and the development of hemp-infused oil formulations. Optimized decarboxylation (98 °C, 65 min) maximized cannabidiol and tetrahydrocannabinol while preserving terpenes. Under identical UAE conditions, ethanol achieved the highest cannabinoid recovery, whereas hydrophilic and hydrophobic deep eutectic solvents selectively enriched phenolic and lipophilic phytochemicals, respectively. These solvent-dependent behaviors were mechanistically explained by differences in polarity, viscosity, and surface tension governing cavitation and mass transfer. The extracted hemp phytochemicals were subsequently incorporated into hemp-infused massage oil formulations containing rice bran oil, which exhibited physicochemical properties comparable to commercial products without synthetic antioxidants. This work provides mechanistic insights into solvent-controlled UAE and a transferable framework for plant-derived bioactive compounds.

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机械洞察到溶剂依赖超声辅助提取大麻植物化学物质：从脱羧到油基系统

对热预处理和溶剂物理化学性质如何控制超声波辅助提取大麻植物化学物质的综合理解仍然有限。本研究系统地考察了脱羧和溶剂性质对提取选择性的影响，并开发了大麻浸渍油配方。优化脱羧（98°C， 65分钟）最大化大麻二酚和四氢大麻酚，同时保留萜烯。在相同的UAE条件下，乙醇获得了最高的大麻素回收率，而亲水和疏水的深共晶溶剂分别选择性地富集了酚类和亲脂类植物化学物质。这些依赖溶剂的行为在机理上可以用极性、粘度和控制空化和传质的表面张力的差异来解释。提取的大麻植物化学物质随后被加入到含有米糠油的大麻按摩油配方中，其物理化学性质与不含合成抗氧化剂的商业产品相当。这项工作为溶剂控制的uae提供了机制见解，并为植物源性生物活性化合物提供了可转移的框架。

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来源期刊

ACS food science & technology

CiteScore

3.30

自引率

0.00%

发文量