Pediatric ALK-Negative Anaplastic Large Cell Lymphoma With Recurrent Cutaneous Relapses: Diagnostic Challenges.

IF 1.2 4区医学 Q3 DERMATOLOGY

Pediatric Dermatology Pub Date : 2026-09-13 DOI:10.1111/pde.70361

Kayla Coffman, Emily Saurborn, Dylan Maldonado, Paul Finch, Shane Cook

引用次数: 0

Abstract

We present the case of a 10-year-old female with anaplastic lymphoma kinase protein (ALK) negative systemic anaplastic large cell lymphoma (ALCL) with cutaneous manifestations that achieved complete remission after multi-agent chemotherapy. Approximately 6 months after remission, the patient experienced a relapse of ALK-negative ALCL confined exclusively to the skin. Four months after completing salvage therapy, she developed a second isolated cutaneous relapse. This case highlights the diagnostic challenge of distinguishing systemic ALCL from primary cutaneous ALCL and other primary cutaneous CD30+ lymphoproliferative disorders.

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小儿alk阴性间变性大细胞淋巴瘤伴皮肤复发：诊断挑战。

我们报告一例10岁女性间变性淋巴瘤激酶蛋白（ALK）阴性系统性间变性大细胞淋巴瘤（ALCL）的皮肤表现，在多药化疗后完全缓解。缓解后大约6个月，患者经历了alk阴性ALCL复发，仅局限于皮肤。在完成挽救治疗4个月后，她出现了第二次孤立的皮肤复发。该病例强调了将全身性ALCL与原发性皮肤ALCL和其他原发性皮肤CD30+淋巴细胞增生性疾病区分开来的诊断挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.