Hye Ja Kang, Maria Jieun Hwang, Ji Sun Kim, Ji Yeon Kim, Marie-Agathe Crampon de Place, Sang Ah Lee
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引用次数: 0
Abstract
Traditionally viewed as a mere relay station of the hippocampal formation, the subiculum is emerging as a computational hub of the medial temporal lobe, essential for multiplexed neural representations guiding behavior. While foundational animal research has revealed that its sophisticated cytoarchitecture allows for conjunctive coding of spatiotemporal information, our understanding of how such neural properties translate to human cognitive function remains incomplete. The evolutionary expansion of its anterior region and the enhancement of its anatomical complexity and widespread neocortical connectivity imply that the function of the human subiculum may extend beyond the spatial domain. In this review, we examine how the subiculum may serve as a scaffold for goal-directed spatiotemporal computations in humans and speculate on its role in supporting abstract cognitive functions such as mental imagery and episodic simulation.
期刊介绍：
Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.
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