The role of inhibition in modeling decision making with spiking neural networks.

Abstract

Decision making (DM) requires coordination of elementary information processes subserved by a distributed network of brain areas. Computational models help to understand these processes, but most of the existing models focus on simulating only one of the many parallel operations. An existing spiking neural network (SNN) model attempts to simulate DM holistically, however it does not take advantage of the significant role of inhibition at the neural level as a possible mechanism underlying DM. To address this limitation, we propose to examine the impact of neural inhibition on decision strategy selection in value-based DM using the mentioned model. In this study we outline the methodology and perform successful in-silico validation of the inhibition hypothesis with the SNN model of DM. To perform the simulation, we use a well-studied multi-attribute choice task and we validate simulation results against human behavioral data. The inhibition model achieved approximately 17% lower mean prediction error than the no-inhibition model (0.55 vs. 0.67) when evaluated on held-out, compensatory-condition data not used for fitting (Wilcoxon signed-rank test, p = 0.009, r = 0.55), with no significant difference observed in the condition used for fitting. These findings indicate that the advantage conferred by inhibition is not attributable to model complexity alone, and support neural inhibition as a plausible, biologically grounded mechanism for adaptive, context-sensitive decision strategy selection.