Early life stress primes future stress vulnerability

IF 29 1区医学 Q1 NEUROSCIENCES

Nature Reviews Neuroscience Pub Date : 2026-08-21 DOI:10.1038/s41583-026-01075-9

Sian Lewis

引用次数: 0

Abstract

Early-life exposure to stressors can lead to increased stress susceptibility in later life, shown here to be mediated in mice by SETD7-mediated monomethylation of H3K4 in dopaminergic neurons of the ventral tegmental area.

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早期的生活压力预示着未来的压力脆弱性。

早期生活暴露于压力源可导致晚年生活中压力敏感性的增加，这在小鼠中是通过setd7介导的腹侧被盖区多巴胺能神经元H3K4的单甲基化介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neuroscience NEUROSCIENCES-

自引率

0.60%

发文量

104

期刊介绍： Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.