Extranodal Marginal Zone Lymphoma of the Breast in a Patient with Chronic Hepatitis C Infection: A Case Report.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Ravneet K Dhanoa, Bipasha Goyal, Prateek Jain, Marilyn Baird-Howell, Mounika Gangireddy
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引用次数: 0

Abstract

Primary breast lymphomas account for less than 1% of all non-Hodgkin lymphomas and 0.04-0.5% of all malignant breast neoplasms. We report a case of breast extranodal marginal zone lymphoma (EMZL) in a 60-year-old woman with chronic hepatitis C virus (HCV) infection. After comprehensive evaluation excluded other known etiologies, chronic HCV infection emerged as the most plausible contributing factor. Epidemiologic and biological evidence supports an association between HCV and B-cell non-Hodgkin lymphomas, particularly marginal zone lymphomas. Our case adds to the limited literature suggesting that HCV should be considered as a potential etiological factor in breast EMZL. We discuss the emerging role of direct-acting antiviral (DAA) therapy in HCV-associated indolent lymphomas and its implications for management.

慢性丙型肝炎感染患者结外边缘区乳腺淋巴瘤1例报告。
原发性乳腺淋巴瘤占所有非霍奇金淋巴瘤的不到1%,占所有乳腺恶性肿瘤的0.04-0.5%。我们报告一例乳腺结外边缘区淋巴瘤(EMZL)在一个60岁的妇女慢性丙型肝炎病毒(HCV)感染。在综合评估排除其他已知病因后,慢性丙型肝炎病毒感染成为最可能的致病因素。流行病学和生物学证据支持HCV与b细胞非霍奇金淋巴瘤,特别是边缘区淋巴瘤之间的关联。我们的病例增加了有限的文献,表明HCV应被视为乳腺EMZL的潜在病因。我们讨论了直接作用抗病毒(DAA)治疗在hcv相关的惰性淋巴瘤中的新作用及其对管理的影响。
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来源期刊
自引率
0.00%
发文量
106
审稿时长
17 weeks
期刊介绍: JCHIMP provides: up-to-date information in the field of Internal Medicine to community hospital medical professionals a platform for clinical faculty, residents, and medical students to publish research relevant to community hospital programs. Manuscripts that explore aspects of medicine at community hospitals welcome, including but not limited to: the best practices of community academic programs community hospital-based research opinion and insight from community hospital leadership and faculty the scholarly work of residents and medical students affiliated with community hospitals.
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