Atypical Lentiginous Melanocytic Proliferations Case Series: Relationship to Type II Dysplastic Nevi and Lentiginous Melanoma.

IF 1.2 4区医学 Q3 DERMATOLOGY

Journal of Cutaneous Pathology Pub Date : 2026-08-18 DOI:10.1111/cup.70198

Maged Daruish, Ella De Ryck, Laura Gadeyne, Julie Lemahieu, Siebe Loontiens, Joni Van Der Meulen, Marc Haspeslagh, Boris C Bastian, Saleem Taibjee

引用次数: 0

Abstract

A recent study described a distinctive subset of dysplastic nevi in older patients, genetically characterized by non-BRAFV600E driver mutations and frequent TERT promoter mutations. It has been proposed that these lesions overlap with the so-called lentiginous dysplastic nevi of the elderly. We explore this relationship in a series of 24 atypical lentiginous melanocytic proliferations, correlating with ex vivo dermoscopy, as well as immunohistochemical and molecular findings. We also discuss the utility of the MPATH-Dx tool to improve consensus for such lesions.

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非典型黄斑性黑色素细胞增生病例系列：与II型发育不良痣和黄斑性黑色素瘤的关系。

最近的一项研究描述了老年患者中发育不良痣的一个独特亚群，其遗传特征是非brafv600e驱动突变和频繁的TERT启动子突变。有人提出，这些病变重叠的所谓的老年性晶状体发育不良痣。我们在一系列24例非典型透镜性黑色素细胞增生中探讨了这种关系，并与体外皮肤镜检查、免疫组织化学和分子检查结果相关联。我们还讨论了MPATH-Dx工具的实用性，以提高对此类病变的共识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cutaneous Pathology 医学-病理学

CiteScore

3.20

自引率

5.90%

发文量

174

审稿时长

3-8 weeks

期刊介绍： Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.