Emotion recognition in multiple sclerosis: The influence of processing speed and cognitive reserve.

IF 1.8 4区心理学 Q2 PSYCHOLOGY

Journal of Neuropsychology Pub Date : 2026-08-20 DOI:10.1111/jnp.70073

Anna Panagiota Palama, Nikolaos Mitsoudis, Ioannis Nikolakakis, Artemios Artemiadis, Panagiotis Ioannidis, Christos Bakirtzis

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Abstract

Social cognitive impairment significantly impacts the quality of life in multiple sclerosis (MS). This study investigated the structural, clinical and functional predictors of emotion recognition in 48 MS patients (26 Relapsing-Remitting, 22 Progressive) and 40 matched healthy controls (HCs). All participants were assessed for emotion recognition (Reading the Mind in the Eyes Test [RMET]). The MS cohort was additionally assessed for information processing speed (IPS) (Symbol Digit Modalities Test [SDMT]) and cognitive reserve (CR) (Cognitive Reserve Index questionnaire [CRIq]). Confounding clinical variables were quantified, including physical disability (Expanded Disability Status Scale [EDSS]), fatigue (Modified Fatigue Impact Scale [MFIS]) and affective symptoms (Depression Anxiety and Stress Scale [DASS-21]). Regional cortical volumes were extracted utilizing 3T MRI automated parcellation. Patients with Progressive MS exhibited profound emotion recognition deficits compared to HCs (p = 0.006). Multivariate regression identified IPS (β = 0.352) and CR (β = 0.289) as the only significant independent predictors of RMET accuracy. These functional variables statistically eclipsed the influence of focal anterior insular atrophy, perceived fatigue and mood symptoms. Emotion recognition impairment in MS is primarily driven by two independent, additive predictors: IPS and CR. Together, these functional determinants outweigh the influence of focal macroscopic cortical damage, fatigue and mood symptoms.

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多发性硬化症的情绪识别：加工速度和认知储备的影响。

社会认知障碍显著影响多发性硬化症（MS）患者的生活质量。本研究调查了48例MS患者（26例复发缓解型，22例进展型）和40例匹配健康对照（hc）的情绪识别的结构、临床和功能预测因素。所有的参与者都被评估了情绪识别（通过眼睛读心测试[RMET]）。对MS队列进行信息处理速度（IPS）（符号数字模态测试[SDMT]）和认知储备（CR）（认知储备指数问卷[CRIq]）的评估。对混杂临床变量进行量化，包括身体残疾（扩展残疾状态量表[EDSS]）、疲劳（修正疲劳影响量表[MFIS]）和情感症状（抑郁、焦虑和压力量表[DASS-21]）。利用3T MRI自动分割提取区域皮质体积。与hcc患者相比，进行性MS患者表现出严重的情绪识别缺陷（p = 0.006）。多因素回归发现IPS （β = 0.352）和CR （β = 0.289）是RMET准确性的唯一显著独立预测因子。这些功能变量在统计上掩盖了局灶性前岛萎缩、感知疲劳和情绪症状的影响。多发性硬化症的情绪识别障碍主要由两个独立的、相加的预测因素驱动：IPS和CR，这些功能决定因素加在一起，超过了局灶性宏观皮层损伤、疲劳和情绪症状的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuropsychology 医学-心理学

CiteScore

4.50

自引率

4.50%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.