Mariana Campello de Oliveira, Maria Olivia Pozzolo Pedro, Kae Leopoldo, Douglas Henrique Crispim, João Maurício Castaldelli-Maia
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引用次数: 0
Abstract
Introduction
Chronic pain and harmful alcohol use are prevalent and disabling conditions with shared neurobiological and social determinants, yet their relationship remains understudied in low- and middle-income countries.
Methods
Cross-sectional data from 90,846 adults with complete data on the 2019 Brazilian National Health Survey were analysed. Chronic pain was categorised as back pain, rheumatism/arthritis and repetitive strain injury/work-related musculoskeletal disorder. Alcohol use was assessed by consumption frequency (six categories), binge drinking and average daily intake. Weighted logistic regression models adjusted for sociodemographic and clinical variables were applied.
Results
A U-shaped association was observed between alcohol consumption frequency and chronic pain: compared with regular-high frequency drinkers (3–5 days/week, reference), higher odds of chronic pain were observed among near-daily (odds ratio [OR] 1.73; 95% confidence interval [CI] 1.17–2.56), occasional (OR 1.61; 95% CI 1.20–2.15), infrequent (OR 1.42; 95% CI 1.11–1.82) and regular-low (1–2 days/week; OR 1.28; 95% CI 1.03–1.60) drinkers. Binge drinking was independently associated with higher odds of chronic pain (OR 1.21; 95% CI 1.03–1.42). Female sex (OR 1.65; 95% CI 1.49–1.83) and depression (OR 2.67; CI 2.32–3.07) showed strong associations with chronic pain. Alcohol quantity (g/day) was not significantly associated with chronic pain in sensitivity analyses.
Discussion and Conclusions
Frequent alcohol use, binge drinking, female sex and depression were independently associated with chronic pain in this low- and middle-income countries population. These associations highlight the importance of addressing behavioural and mental health patterns in pain management. Future longitudinal studies are needed to determine the directionality of these associations.
慢性疼痛和有害酒精使用是普遍存在的致残状况,具有共同的神经生物学和社会决定因素,但在低收入和中等收入国家,它们之间的关系仍未得到充分研究。方法分析2019年巴西国家健康调查中90846名成年人的横断面数据。慢性疼痛分为背部疼痛、风湿病/关节炎和重复性劳损/与工作相关的肌肉骨骼疾病。通过饮酒频率(六类)、酗酒和平均每日摄入量来评估酒精使用情况。采用经社会人口统计学和临床变量调整的加权逻辑回归模型。结果在饮酒频率和慢性疼痛之间观察到u型相关性:与经常高频饮酒者(3-5天/周,参考)相比,近每天饮酒者(比值比[OR] 1.73; 95%可信区间[CI] 1.17-2.56)、偶尔饮酒者(比值比[OR] 1.61; 95%可信区间[CI] 1.20-2.15)、不经常饮酒者(比值比[OR] 1.42; 95% CI 1.11-1.82)和经常低频率饮酒者(1-2天/周;比值比1.28;95% CI 1.03-1.60)出现慢性疼痛的几率更高。酗酒与较高的慢性疼痛发生率独立相关(OR 1.21; 95% CI 1.03-1.42)。女性(OR 1.65; 95% CI 1.49-1.83)和抑郁(OR 2.67; CI 2.32-3.07)与慢性疼痛有很强的相关性。在敏感性分析中,酒精量(g/天)与慢性疼痛无显著相关性。讨论和结论在低收入和中等收入国家人群中,频繁饮酒、酗酒、女性性行为和抑郁与慢性疼痛独立相关。这些关联突出了在疼痛管理中处理行为和心理健康模式的重要性。未来的纵向研究需要确定这些关联的方向性。
期刊介绍:
Drug and Alcohol Review is an international meeting ground for the views, expertise and experience of all those involved in studying alcohol, tobacco and drug problems. Contributors to the Journal examine and report on alcohol and drug use from a wide range of clinical, biomedical, epidemiological, psychological and sociological perspectives. Drug and Alcohol Review particularly encourages the submission of papers which have a harm reduction perspective. However, all philosophies will find a place in the Journal: the principal criterion for publication of papers is their quality.