Quantitative Analysis of Cholesteryl Esters in Breast Milk from Japanese Mothers

IF 3 Q2 FOOD SCIENCE & TECHNOLOGY

ACS food science & technology Pub Date : 2026-08-21 Epub Date: 2026-07-10 DOI:10.1021/acsfoodscitech.6c00387

Divyavani Gowda, Siddabasave Gowda B. Gowda, Chihiro Miyashita, Atsuko Ikeda, Reiko Kishi, Shu-Ping Hui

{"title":"Quantitative Analysis of Cholesteryl Esters in Breast Milk from Japanese Mothers","authors":"Divyavani Gowda, Siddabasave Gowda B. Gowda, Chihiro Miyashita, Atsuko Ikeda, Reiko Kishi, Shu-Ping Hui","doi":"10.1021/acsfoodscitech.6c00387","DOIUrl":null,"url":null,"abstract":"<p>Cholesterol esters (CEs) in breast milk are vital for\r\ninfant brain\r\ndevelopment and myelination, yet data from Japanese mothers are limited.\r\nThis study quantified eight CEs using a rapid in-house targeted liquid\r\nchromatography/mass spectrometry method (10 min runtime) in breast\r\nmilk from 159 healthy mothers aged 19–47 years in Sapporo,\r\nJapan. CE 20:4 was the most abundant cholesteryl ester in breast milk,\r\nfollowed by CE 16:0. Total CE levels were significantly lower in older\r\nmothers (40–47 y) compared to younger mothers (21–29\r\ny). Mothers with normal body mass index had higher CE levels, while\r\nsmoking mothers had significantly higher total and individual CE levels.\r\nDelivery type (caesarean vs vaginal) affected CE composition, whereas\r\nparity did not. These findings indicate that maternal characteristics\r\nand lifestyle factors may influence breast milk CE profiles, emphasizing\r\nthe role of maternal health in determining lipid supply essential\r\nfor infant neurodevelopment and cardiovascular health.</p>","PeriodicalId":72048,"journal":{"name":"ACS food science & technology","volume":"6 8","pages":"2444–2454"},"PeriodicalIF":3.0000,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS food science & technology","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsfoodscitech.6c00387","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/7/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Cholesterol esters (CEs) in breast milk are vital for infant brain development and myelination, yet data from Japanese mothers are limited. This study quantified eight CEs using a rapid in-house targeted liquid chromatography/mass spectrometry method (10 min runtime) in breast milk from 159 healthy mothers aged 19–47 years in Sapporo, Japan. CE 20:4 was the most abundant cholesteryl ester in breast milk, followed by CE 16:0. Total CE levels were significantly lower in older mothers (40–47 y) compared to younger mothers (21–29 y). Mothers with normal body mass index had higher CE levels, while smoking mothers had significantly higher total and individual CE levels. Delivery type (caesarean vs vaginal) affected CE composition, whereas parity did not. These findings indicate that maternal characteristics and lifestyle factors may influence breast milk CE profiles, emphasizing the role of maternal health in determining lipid supply essential for infant neurodevelopment and cardiovascular health.

查看原文本刊更多论文

日本母亲母乳中胆固醇酯的定量分析

母乳中的胆固醇酯（CEs）对婴儿大脑发育和髓鞘形成至关重要，但来自日本母亲的数据有限。本研究使用快速内部靶向液相色谱/质谱法（10分钟运行时间）对日本札幌159名19-47岁健康母亲的母乳中的8种ce进行了定量分析。母乳中胆固醇酯含量最高的是CE 20:4，其次是CE 16:0。年龄较大的母亲（40-47岁）的总CE水平明显低于年龄较小的母亲（21 - 29岁）。体重指数正常的母亲的CE水平更高，而吸烟的母亲的总体和个体CE水平明显更高。分娩方式（剖腹产或阴道）影响CE组成，而产次不影响。这些发现表明，母亲的特征和生活方式因素可能影响母乳CE谱，强调了母亲健康在决定婴儿神经发育和心血管健康所必需的脂质供应方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS food science & technology

CiteScore

3.30

自引率

0.00%

发文量