Pulsed Radiofrequency for Post-Stroke Complications: From Neuromodulation to Functional Recovery.

IF 7.4 2区医学 Q1 CLINICAL NEUROLOGY

Current Neurology and Neuroscience Reports Pub Date : 2026-08-08 DOI:10.1007/s11910-026-01509-y

Rujuan Liu, Huali Gu, Xingyu Kang, Wei Chen, Chengfei Gao, Xiao Han, Lijun Meng, Ting Zhu, Zhengyu Gao

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引用次数: 0

Abstract

Purpose of review: This review synthesizes the mechanisms, applications, and evidence gaps regarding pulsed radiofrequency (PRF) in the rehabilitation of post-stroke complications to guide its standardized integration.

Recent findings: PRF, a minimally invasive neuromodulation technique, modulates neuronal excitability without thermal damage. Emerging evidence highlights multi-target effects, including improved microcirculation, suppressed neuroinflammation, and regulated neurotrophic factors. Clinically, PRF effectively alleviates refractory post-stroke pain and may indirectly ameliorate post-stroke depression while facilitating motor recovery. Image-guided procedures targeting specific nerves demonstrate favorable safety profiles. Despite promising outcomes for stroke rehabilitation, current evidence relies primarily on small case series and preclinical studies. Significant gaps remain in standardized protocols and high-quality randomized controlled trials. Further validation of long-term efficacy and safety is essential to establish PRF's definitive role in comprehensive post-stroke management.

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脉冲射频治疗卒中后并发症：从神经调节到功能恢复。

综述目的：本文综述了脉冲射频（PRF）在脑卒中后并发症康复中的机制、应用和证据缺口，以指导其标准化整合。最近发现：PRF是一种微创神经调节技术，可以在不造成热损伤的情况下调节神经元的兴奋性。新出现的证据强调了多靶点效应，包括改善微循环、抑制神经炎症和调节神经营养因子。临床上，PRF可有效缓解难治性脑卒中后疼痛，并可间接改善脑卒中后抑郁，同时促进运动恢复。针对特定神经的图像引导手术显示出良好的安全性。尽管中风康复的结果很有希望，但目前的证据主要依赖于小病例系列和临床前研究。在标准化方案和高质量随机对照试验方面仍存在重大差距。进一步验证PRF的长期疗效和安全性对于确定PRF在卒中后综合管理中的决定性作用至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.