Assessment of full-field stimulus test results in Stargardt disease: correlations with full-field electroretinography, multifocal electroretinography, and optical coherence tomography.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Documenta Ophthalmologica Pub Date : 2026-08-01 DOI:10.1007/s10633-026-10134-6

Zekeriya Cetinkaya, Neslihan Sinim Kahraman, Ayşe Öner

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引用次数: 0

Abstract

Purpose: The aim of this study is to evaluate the results of the Full-Field Stimulus test (FST) in patients with Stargardt disease (STGD), and to compare these results with findings obtained from other ophthalmologicalassesments.

Methods: Twenty-six eyes with STGD and 26 eyes from healthy controls were included in the study. Following a routine ophthalmologic examination, all participants underwent optical coherence tomography, full-field and multifocal electroretinography, and full-field stimulus testing.

Results: The mean age was 29.3 years in the STGD group and 27.1 years in the control group. All participants successfully completed the FST procedure. Visual acuity and central macular thickness were significantly lower in the STGD group compared to the control group (p < 0,01). Multifocal electroretinography (mfERG) analysis revealed significantly decreased mean P1-wave amplitudes and prolonged mean P1-wave implicittimes across all rings in the STGD group. Additionally, FST threshols for white, blue and red stimuli were significantly lower in the STGD group than in the control group (p < 0,01). Correlation analysis revealed a positive relationship between FST results and visual acuity, mfERG amplitudes and central macular thickness.

Conclusion: FST is a simple, reliable and rapid test that can be applied in patients with low visual acuity. It effectively measures retinal sensitivity in patients with STGD. Given its practicality FST can be safely used to monitor the disease progression and treatment response in inherited retinal diseases.

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Stargardt病全视野刺激试验结果的评估：与全视野视网膜电图、多焦视网膜电图和光学相干断层扫描的相关性

目的：本研究的目的是评价Stargardt病（STGD）患者的全视野刺激试验（FST）结果，并将这些结果与其他眼科评估结果进行比较。方法：选取STGD患者26只眼和健康对照者26只眼。在常规眼科检查之后，所有参与者都进行了光学相干断层扫描、全视野和多焦点视网膜电图以及全视野刺激测试。结果：STGD组平均年龄29.3岁，对照组平均年龄27.1岁。所有参与者都成功完成了FST程序。结论：FST是一种简便、可靠、快速的检测方法，可用于低视力患者。它能有效测量STGD患者的视网膜敏感性。鉴于其实用性，FST可以安全地用于监测遗传性视网膜疾病的疾病进展和治疗反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).