The Neurology of Menopause.

IF 7.4 2区医学 Q1 CLINICAL NEUROLOGY

Current Neurology and Neuroscience Reports Pub Date : 2026-07-24 DOI:10.1007/s11910-026-01506-1

Hannah J Roeder, Enrique C Leira

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引用次数: 0

Abstract

Purpose of review: Menopause is a neuroendocrine process with important implications for neurological health. This review examines the complex, multidirectional relationships between menopause and major central nervous system conditions, including stroke, migraine, epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease.

Recent findings: Menopause may mark an inflection point for vascular injury, neurodegeneration, and disability accumulation in several neurological conditions. Perimenopausal hormonal fluctuations may exacerbate migraines and seizures in susceptible women. Research increasingly supports the critical window hypothesis for estrogen therapy and highlights the importance of distinguishing reproductive and chronological aging when interpreting neurologic trajectories. Menopause represents an important transition for many conditions. Hormone therapy has heterogenous effects with cognitive benefit in premature ovarian insufficiency, harm related to stroke risk in older women, and greater uncertainty in other conditions. Therefore, individualized risk-benefit assessment is essential. Research gaps remain significant, and menopause should be a priority area for neurologic research.

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更年期的神经学。

综述目的：绝经是一个神经内分泌过程，对神经系统健康具有重要意义。本文综述了更年期与主要中枢神经系统疾病（包括中风、偏头痛、癫痫、多发性硬化症、帕金森病和阿尔茨海默病）之间复杂的多向关系。最近的研究发现：更年期可能标志着血管损伤、神经变性和几种神经系统疾病的残疾积累的拐点。围绝经期荷尔蒙波动可能会加剧易受影响妇女的偏头痛和癫痫发作。越来越多的研究支持雌激素治疗的关键窗口假说，并强调在解释神经系统轨迹时区分生殖和时间衰老的重要性。更年期代表了许多情况下的重要转变。激素治疗对卵巢功能不全患者有认知益处，对老年妇女有卒中风险的危害，对其他情况有更大的不确定性。因此，个性化的风险-收益评估是必要的。研究差距仍然很大，更年期应该是神经学研究的优先领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.