Vladimir Maslivetc, Susana Tejeda-Garibay, Adeola Fagbayibo, James J. La Clair, Katrina K. Hoyer, Joseph P. Noel
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引用次数: 0
Abstract
Coccidioidomycosis, or Valley fever, is a fungal respiratory
disease
caused by Coccidioides immitis or Coccidioides posadasii. Clinical manifestations range
from asymptomatic infection to chronic pulmonary disease. Despite
the increasing endemic range and affected population, therapeutic
strategies display moderate efficacy and adverse side effects. This
study explores California’s rich botanical diversity as a source
for agents that inhibit the early stages of Coccidioides development. We established a screening protocol containing a colorimetric
metabolism assay and microscopic imaging. We then applied this protocol
to extracts derived from local plants in San Diego, California, and
discovered a potent inhibitor, persenone A, from avocados.
球孢子菌病，又称谷热，是一种由球孢子虫引起的呼吸道真菌疾病。临床表现从无症状感染到慢性肺部疾病。尽管流行范围和受影响人群不断增加，但治疗策略显示出中等疗效和不良副作用。本研究探讨了加州丰富的植物多样性作为抑制球虫发育早期阶段的代理人的来源。我们建立了一个包含比色代谢测定和显微成像的筛选方案。然后，我们将该方案应用于从加利福尼亚州圣地亚哥当地植物中提取的提取物，并从鳄梨中发现了一种有效的抑制剂，person one a。
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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