Exploring electrode montages to optimize the non-invasive clinical recording of auditory evoked AP/wave I

IF 2.3 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2026-01-01 Epub Date: 2026-07-03 DOI:10.1016/j.cnp.2026.07.001

Ludivine Beaud-Henry, Aurélien Mulliez, Alann Renault, Katia Bouton, Paul Avan, Fabrice Giraudet

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引用次数: 0

Abstract

Objectives

Recent advances in electrocochleography (ECochG), particularly the development of minimally invasive ear-canal electrodes, have renewed interest in the objective assessment of auditory disorders such as endolymphatic hydrops, auditory neuropathy spectrum disorders, and cochlear synaptopathy. This study aimed to identify the optimal recording configuration for maximizing compound action potential (AP)/auditory brainstem response (ABR) wave I amplitude in normal-hearing adults.

Methods

Forty-seven normal-hearing young adults (24 women) underwent ABR and ECochG recordings using a conventional clinical evoked-potential system. Six electrode montages combining earlobe, ear-canal, Cz, and Fz electrodes were evaluated. Rarefaction and condensation click stimuli were presented separately. AP/wave I latency and baseline-to-peak amplitude were compared according to recording protocol, electrode montage, click polarity, and sex.

Results

AP/wave I latency remained stable across recording protocols, electrode configurations, click polarities, and sex. In contrast, AP/wave I amplitude was strongly influenced by recording conditions. Rarefaction clicks consistently produced larger amplitudes than condensation clicks. Ear-canal electrodes significantly enhanced AP/wave I amplitude compared with conventional earlobe electrodes, with amplitude enhancement ratios ranging from 1.40 ± 0.55 to 2.14 ± 1.90. The vertical ear-canal/Fz montage provided the most robust responses in both ABR and ECochG recordings.

Conclusions

ECochG recordings obtained with an ear-canal electrode and rarefaction click stimulation optimize AP/wave I amplitude while maintaining a non-invasive and clinically applicable procedure.

Significance

Optimized ECochG acquisition with a non-invasive ear-canal electrode enhances the identification and quantification of AP/wave I and may improve the electrophysiological assessment of auditory neuropathy, cochlear synaptopathy, and endolymphatic hydrops in routine clinical practice.

查看原文本刊更多论文

探索电极蒙太奇优化听觉诱发AP/波I的无创临床记录。

目的：在临床常规中，耳蜗电图（Ecog）的使用引起了人们对新型微创电极（金耳尖电极）的重新关注，该电极可以记录复杂的病理实体，如耳蜗内积液、听神经病变、耳蜗突触病，还可以监测颅内压变化。为了最大限度地减少方法因素造成的差异，本研究旨在比较正常听力成年人（男女）耳垂和耳道电极记录的复合动作电位(AP)/波I振幅以及点击极性（稀薄与凝聚）的影响。结果：所有电生理指标均采用常规临床诱发电位测量系统采集。在听觉脑干反应（ABR）和脑电图记录方案之间，AP/波I潜伏期的结果保持相对稳定，女性的潜伏期更短，极性更稀薄。我们的研究结果支持在ABR和Ecog协议下使用耳道电极；垂直电极蒙太奇和稀薄点击极性始终为男女的AP/波I提供显著更高的振幅。讨论：虽然Ecog长期以来被用于客观诊断和监测内淋巴积液，但Ecog也可用于诊断听神经病变。最近的动物研究结果表明，AP/波I的出现是年龄相关或噪声诱导的耳蜗突触丧失（耳蜗突触病）的敏感指标。因此，有必要优化Ecog方案，以更敏感地评估AP/波I的形态，作为提高对不同病理实体理解的不可或缺的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.