Long-chain omega-3-enriched erythrocyte fatty acid pattern is associated with lower odds of obesity and metabolic dysfunction-associated steatotic liver disease.
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引用次数: 0
Abstract
Background: Erythrocyte membrane fatty acids (FAs) reflect medium-term FA status and may capture integrated metabolic profiles beyond individual FAs. Their relationships with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) remain insufficiently characterized.
Methods: We analyzed nationally representative U.S. adults with available erythrocyte FA measurements. Principal component analysis (PCA) was applied to 21 FAs, and the first five components were retained. Survey-weighted regression models evaluated associations of principal component (PC) scores with body weight status and MASLD defined by vibration-controlled transient elastography and cardiometabolic criteria. Pearson correlations assessed relationships between PC scores and energy-adjusted dietary FA intake. False discovery rate (FDR) correction was applied.
Results: Among 4,979 adults, a long-chain omega-3-enriched pattern (PC2) was independently associated with lower odds of obesity (OR per 1-SD increase 0.74; 95% CI 0.68-0.81; q < 0.001) and was modestly correlated with higher dietary long-chain omega-3 intake (r = 0.22). Among 3,448 participants with valid elastography data, PC2 was similarly associated with lower odds of MASLD (OR per 1-SD increase 0.73; 95% CI 0.67-0.80; q < 0.001). PC3, characterized by higher eicosadienoic acid, gondoic acid, and linoleic acid, was also inversely associated with both obesity and MASLD.
Conclusion: In this cross-sectional study of U.S. adults, a long-chain omega-3-enriched erythrocyte FA pattern was associated with 26% lower odds of obesity and 27% lower odds of MASLD. These findings suggest that erythrocyte FA patterns may reflect integrated dietary and metabolic FA status associated with obesity and MASLD.
背景：红细胞膜脂肪酸（FAs）反映中期FA状态，并可能捕获个体FAs之外的综合代谢谱。它们与肥胖和代谢功能障碍相关的脂肪变性肝病（MASLD）的关系仍未充分表征。方法：我们分析了具有全国代表性的美国成年人的红细胞FA测量值。对21个FAs进行主成分分析（PCA），保留前5个成分。调查加权回归模型评估了主成分（PC）得分与体重状况和MASLD（由振动控制的瞬态弹性成像和心脏代谢标准定义）之间的关联。Pearson相关性评估了PC分数与能量调整膳食FA摄入量之间的关系。应用错误发现率（FDR）校正。结果：在4,979名成年人中，长链omega-3富集模式（PC2）与较低的肥胖几率独立相关(OR每1-SD增加0.74;95% CI 0.68-0.81； q结论：在这项针对美国成年人的横断面研究中，长链omega-3富集红细胞FA模式与26%的肥胖几率降低和27%的MASLD几率降低相关。这些发现表明红细胞FA模式可能反映了与肥胖和MASLD相关的膳食和代谢FA状态。
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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