Botryolides F and G from the Fungus Bartalinia robillardoides with Anthelmintic Activity

IF 3.7 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-07-08 DOI:10.1021/acs.jnatprod.6c00508

Coralie Pavesi, Victor Flon, Frederic Fercoq, Chloé Borde, Alexandre Escargueil, Pascal Retailleau, Lili Sun, Coralie Martin, Xavier Franck, Soizic Prado

引用次数: 0

Abstract

The chemical investigation of the fungusBartalinia robillardoides CBS 122686 led to the isolation of two new decarestrictines bearing an unusual three-carbon unit appended to the polyketide moiety and named Botryolides F and G. The compounds were structurally characterized, and their absolute configurations were determined through a combination of spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analyses. Botryolide G was assessed for anthelmintic activity and exhibited promising efficacy at a concentration of 100 μg/mL, with no significant cytotoxicity observed.

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具有驱虫活性的巴塔利菌中的肉毒素F和G。

通过对bartalinia robillardoides CBS 122686的化学研究，分离出了两个新的decarestricines，其聚酮部分附加了一个不寻常的三碳单元，并命名为Botryolides F和G.化合物进行了结构表征，并通过光谱方法、单晶x射线衍射和电子圆二色性（ECD）分析确定了它们的绝对构型。Botryolide G在100 μg/mL浓度下具有良好的驱虫效果，无明显的细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.