Oleraciamides A and B: Confirmation and Revision of Structures

IF 3.7 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-07-02 DOI:10.1021/acs.jnatprod.6c00548

Sai Kiran Kunuru, Laxman D. Nandawadekar, Mikhail E. Elyashberg, Craig M. Williams, D. Srinivasa Reddy, Roderick W. Bates

引用次数: 0

Abstract

The proposed structure of oleraciamide A was confirmed by the computational methods and synthesis. However, the structure of oleraciamide B was found to be incorrect and, therefore, reassigned as an amine N-oxide. The structure of the reassigned natural product was confirmed through comparison with authentic material obtained via total synthesis.

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耐酸酰胺A和B：结构的确认和修订。

通过计算方法和合成证实了所提出的耐酸酰胺A的结构。然而，耐酸酰胺B的结构被发现是不正确的，因此被重新分配为胺n -氧化物。通过与全合成获得的真实材料的比较，确定了重新分配的天然产物的结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.