Assessing the Diagnostic Performance of Triglyceride–Glucose–Based Indices for Early Detection of Metabolic Syndrome in Paediatric Down Syndrome

IF 2.4 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research Pub Date : 2026-09-08 Epub Date: 2026-06-24 DOI:10.1111/jir.70134

Valeria Calcaterra, Lucia Labati, Alessandra Anna Gazzarri, Alice De Lorenzo, Ilaria Anna Maria Scavone, Gianvincenzo Zuccotti

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引用次数: 0

Abstract

Background

Down syndrome (DS) youth have an increased risk of metabolic syndrome (MetS). This study assessed the diagnostic performance of the triglyceride–glucose index (TyG) and its derivatives—TyG-BMI, TyG-waist circumference (WC) and TyG-waist-to-height ratio (WHtR) in detecting MetS compared with traditional markers.

Methods

We retrospectively analysed data from 60 DS patients and 40 controls; IR was estimated using HOMA-IR, TyG, TyG-BMI, TyG-WC and TyG-WHtR indices. MetS was defined by the presence of at least three of the following criteria: BMI z-score ≥ 2 SD and/or WC/H ratio ≥ 0.5; fasting glucose > 100 mg/dL and/or pathological HOMA-IR; dyslipidaemia; hypertension.

Results

MetS prevalence was 15% in DS. HOMA-IR showed the highest sensitivity (0.667) and specificity (0.80) to detect MetS, while TyG demonstrated similar performance (sensitivity 0.667; specificity 0.843) and the best overall accuracy (0.817). Composite indices showed moderate accuracy but high specificity.

Conclusions

TyG, being simple and cost-effective, may be a valuable alternative for early MetS detection in DS.

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评估以甘油三酯-葡萄糖为基础的指标对儿童唐氏综合征代谢综合征早期检测的诊断性能

背景：唐氏综合征（DS）青少年发生代谢综合征（MetS）的风险增加。本研究评估了甘油三酯-葡萄糖指数（TyG）及其衍生物——TyG- bmi、TyG-腰围（WC）和TyG-腰高比（WHtR）在检测MetS方面的诊断性能，并与传统标志物进行了比较。方法：回顾性分析60例退行性椎体滑移患者和40例对照者的资料；IR采用HOMA-IR、TyG、TyG- bmi、TyG- wc和TyG- whtr指数估算。MetS通过至少存在以下三个标准来定义：BMI z-score≥2 SD和/或WC/H比值≥0.5；空腹血糖100 mg/dL和/或病理性HOMA-IR；dyslipidaemia;高血压。结果：DS患者met患病率为15%。HOMA-IR检测MetS的灵敏度（0.667）和特异度（0.80）最高，TyG检测MetS的灵敏度（0.667）和特异度（0.843）相近，总体准确率（0.817）最高。综合指标准确度中等，特异度高。结论：TyG检测方法简单，成本低，可能是DS早期检测MetS的有价值的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Intellectual Disability Research Multiple-

CiteScore

5.60

自引率

5.60%

发文量

期刊介绍： The Journal of Intellectual Disability Research is devoted exclusively to the scientific study of intellectual disability and publishes papers reporting original observations in this field. The subject matter is broad and includes, but is not restricted to, findings from biological, educational, genetic, medical, psychiatric, psychological and sociological studies, and ethical, philosophical, and legal contributions that increase knowledge on the treatment and prevention of intellectual disability and of associated impairments and disabilities, and/or inform public policy and practice. Expert reviews on themes in which recent research has produced notable advances will be included. Such reviews will normally be by invitation.