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Naringenin Alleviates Acute Ethanol Exposure-induced Nerve Injury Through Regulating Neuroinflammation via PI3K/AKT Pathway-Mediated Modulation of Microglial M1/M2 Polarization

IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Food Science and Human Wellness Pub Date : 2026-04-01 DOI:10.26599/fshw.2026.9251116
Changming Yang, Hongxi Zheng, Han Wang, Yinjia He, Xiaodong Liu, Linqing Miao
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柚皮素通过PI3K/AKT通路介导的小胶质细胞M1/M2极化调节神经炎症，减轻急性乙醇暴露诱导的神经损伤
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来源期刊
Food Science and Human Wellness
Food Science and Human Wellness Agricultural and Biological Sciences-Food Science
CiteScore
8.30
自引率
5.70%
发文量
80
审稿时长
28 days
期刊介绍： Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers.
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secondary antibody
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Griess reagent
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anti-Phospho-PI3 Kinase p85/p55
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anti-PI3 Kinase p85
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B27
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DMEM/F-12 medium
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DMEM
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phosphate buffered saline
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anti-NeuN
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rotarod apparatus
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LY294002
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wortmannin
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PVDF membrane
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ALDH assay kit
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SOD assay kit
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35
ImageJ
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confocal microscope
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Nikon AXR confocal microscope
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CatWalk system
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CatWalk XT 9.0 software
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bovine serum albumin
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Cell proliferation assay kit
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CellTiter 96 AQueous one solution cell proliferation assay kit
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anti-ARG1
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44
anti-CD16
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45
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anti-PSD95
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LightCycler 480 System
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protease and phosphatase inhibitors
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sulfatase
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β-glucuronidase
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SYBR Premix Ex Taq kit
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BCA Protein Assay Kit
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DAPI
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Fluo-4
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GlutaMAX
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microplate photometer
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Pierce BCA Protein Assay Kit
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SuperScript III
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SuperSignal West Pico PLUS Chemiluminescent Substrate
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61
TUNEL BrightGreen Apoptosis Detection Kit
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SDS-PAGE loading buffer
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L(+)-Ascorbic acid
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acetonitrile
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ethyl acetate
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methanol
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IL-10 ELISA kit
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22
5,7-Dimethoxycoumarin
487-06-9
￥29.00-￥14202.00
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Naringenin
480-41-1
￥23.00-￥32240.00
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