The Diagnostic Yield of Fine Needle Aspiration and Biopsy Needles According to Needle Passes Number in Diagnosing Pancreatic Adenocarcinoma

IF 1.2 4区医学 Q4 CELL BIOLOGY

Cytopathology Pub Date : 2026-10-05 Epub Date: 2026-06-19 DOI:10.1111/cyt.70102

Wisam Sbeit, Moaad Farraj, Tawfik Khoury

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引用次数: 0

Abstract

Introduction

Endoscopic ultrasound guided fine needle aspiration/biopsy (EUS-FNA/FNB) is the main diagnostic tool for solid pancreatic lesions. However, it is associated with a limited diagnostic yield.

Aim

We aimed to assess the optimal needle passes number of FNA\FNB needles to achieve maximum diagnostic yield.

Methods

We performed a retrospective study including all patients who were diagnosed with pancreatic adenocarcinoma by EUS-FNA/FNB. The diagnostic yield was reported for all needles according to the number of needle passes.

Results

Overall, 227 patients underwent EUS-FNA/FNB. FNBs in 85 patients (37.4%), and FNA in 142 patients (62.5%). The needle number passes in the FNB was 1.46 ± 0.70 versus 2.11 ± 1.12 in the FNA group (p < 0.0001). One, two, and three needle passes yielded a diagnosis rate of malignancy in 76.8%, 68.4% and 70% of cases respectively for histology, while for cytology, the yield was 78.6%, 89.4% and 100%, respectively. For FNB needle types, the acquire needle outperformed the other needle, as the histological yield for one pass was 78.6%, 80% for two passes, and 57.1% for three passes, while for cytology, the yield was 79.3%, 90%, and 100% for one, two and three passes, respectively. For the FNA needle, the cytological yield was 88.7% for one pass, and higher for two and three passes.

Conclusion

The number of needle passes for FNB (maximum three passes) was lower than FNA needles (3–4 passes) to obtain an optimal diagnostic yield.

查看原文本刊更多论文

细针抽吸和活检针对胰腺腺癌的诊断及针过数分析。

内镜超声引导下细针穿刺活检（EUS-FNA/FNB）是胰腺实性病变的主要诊断工具。然而，它与有限的诊断率有关。目的：我们旨在评估FNA / FNB针的最佳针道数，以达到最大的诊断率。方法：我们进行了一项回顾性研究，包括所有通过EUS-FNA/FNB诊断为胰腺腺癌的患者。根据针道次数报告所有针的诊断率。结果：总体而言，227例患者接受了EUS-FNA/FNB。fnb 85例（37.4%），FNA 142例（62.5%）。FNB组的针道次数为1.46±0.70次，FNA组的针道次数为2.11±1.12次(p)。结论：FNB组的针道次数（最多3次）低于FNA组（3-4次），以获得最佳的诊断率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytopathology 生物-病理学

CiteScore

2.30

自引率

15.40%

发文量

107

审稿时长

6-12 weeks

期刊介绍： The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.