Neural correlates of meditation-induced changes in self-related traits: a resting state fMRI study.

IF 4.1 2区心理学 Q2 PSYCHIATRY

Mindfulness Pub Date : 2026-06-04 DOI:10.1007/s12671-026-02885-9

Diane Joss

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引用次数: 0

Abstract

Objectives: Meditation training can influence various self-related traits, such as self-judgment (SJ), self-kindness (SK), rumination (RUM) and reflection (REF), but little is known about the underlying neural mechanisms. This study aimed to elucidate the neural correlates of changes in traits of SJ, SK, RUM, and REF in response to mindfulness meditation training.

Method: Secondary data analyses were conducted on pre- and post-intervention questionnaires and resting state fMRI data collected in a prior mechanistic neuroimaging Randomized Controlled Trial (RCT) that compared 8 weeks of Mindfulness-Based Stress Reduction (MBSR, n=39) to an active control program of Stress Management Education (SME) (n=25) among healthy adults. Voxelwise Amplitudes of Low Frequency Fluctuations (ALFF) were calculated from resting state fMRI as a measurement of magnitudes of spontaneous brain activity.

Results: Linear mixed effects model analyses found no significant group by time interaction effects with any of the outcome measures. The MBSR group had significant improvements in all four trait measures, whereas the control group only had significant improvements in SJ and SK (p < 0.05). Linear regression analyses were conducted to predict voxelwise ALFF changes (ΔALFF) using questionnaire score changes (Δ). Within the MBSR group, ΔSK was positively associated with ΔALFF at the right dorsolateral prefrontal cortex (DLPFC), while ΔRUM and ΔREF respectively had negative and positive associations with ΔALFF in the Temporal Parietal Junction (TPJ). Different neural correlates were observed in the control group.

Conclusions: These findings suggest that meditation training can influence self-related traits through adaptive changes in brain regions involved in executive functioning (DLPFC) and empathy (TPJ).

Preregistration: The original RCT was registered as NCT01488422 at ClinicalTrials.gov, accessible at: https://clinicaltrials.gov/study/NCT01488422.

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冥想诱导自我相关特征变化的神经相关因素：静息状态功能磁共振成像研究。

目的：冥想训练可以影响自我判断（SJ）、自我友善（SK）、反刍（RUM）和反思（REF）等自我相关特征，但其潜在的神经机制尚不清楚。本研究旨在阐明正念冥想训练对SJ、SK、RUM和REF特征变化的神经相关性。方法：对先前机械神经影像学随机对照试验（RCT）中收集的干预前后问卷和静息状态fMRI数据进行二次数据分析，该试验将健康成人中8周的正念减压（MBSR, n=39）与积极控制的压力管理教育（SME）计划（n=25）进行比较。从静息状态fMRI计算低频波动的体素幅度（ALFF），作为自发脑活动幅度的测量。结果：线性混合效应模型分析没有发现显著组间的时间交互效应与任何结果测量。正念减压组四项指标均有显著改善，而对照组仅在SJ和SK方面有显著改善（p < 0.05）。采用问卷评分变化（Δ）进行线性回归分析，预测ALFF的体向变化（ΔALFF）。在MBSR组中，ΔSK与右侧背外侧前额叶皮层（DLPFC）的ΔALFF呈正相关，而ΔRUM和ΔREF分别与颞顶叶交界处（TPJ）的ΔALFF呈负相关和正相关。在对照组观察到不同的神经相关。结论：这些研究结果表明冥想训练可以通过参与执行功能（DLPFC）和共情（TPJ）的大脑区域的适应性变化来影响自我相关特征。预注册：最初的RCT在ClinicalTrials.gov上注册为NCT01488422，可访问：https://clinicaltrials.gov/study/NCT01488422。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mindfulness Multiple-

CiteScore

6.10

自引率

19.40%

发文量

224

期刊介绍： Mindfulness seeks to advance research, clinical practice, and theory on mindfulness. It is interested in manuscripts from diverse viewpoints, including psychology, psychiatry, medicine, neurobiology, psychoneuroendocrinology, cognitive, behavioral, cultural, philosophy, spirituality, and wisdom traditions. Mindfulness encourages research submissions on the reliability and validity of assessment of mindfulness; clinical uses of mindfulness in psychological distress, psychiatric disorders, and medical conditions; alleviation of personal and societal suffering; the nature and foundations of mindfulness; mechanisms of action; and the use of mindfulness across cultures. The Journal also seeks to promote the use of mindfulness by publishing scholarly papers on the training of clinicians, institutional staff, teachers, parents, and industry personnel in mindful provision of services. Examples of topics include: Mindfulness-based psycho-educational interventions for children with learning, emotional, and behavioral disorders Treating depression and clinical symptoms in patients with chronic heart failure Yoga and mindfulness Cognitive-behavioral mindfulness group therapy interventions Mindfulnessness and emotional regulation difficulties in children Loving-kindness meditation to increase social connectedness Training for parents and children with ADHD Recovery from substance abuse Changing parents’ mindfulness Child management skills Treating childhood anxiety and depression