Long non-coding RNA PURPL in cancer and cellular regulation: Mechanistic insights and therapeutic potential.

IF 2.5 4区工程技术 Q3 PHARMACOLOGY & PHARMACY

Bioimpacts Pub Date : 2026-04-10 eCollection Date: 2026-01-01 DOI:10.34172/bi.33252

Nazila Valatabar, Reza Safaralizadeh, Amir Ali Mokhtarzadeh, Mohammad Ali Hosseinpour Feizi

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引用次数: 0

Abstract

Long non-coding RNAs (lncRNAs) constitute a large fraction of the mammalian transcriptome and are increasingly recognized as critical regulators of gene expression and cellular homeostasis. Dysregulation of lncRNAs has been strongly implicated in cancer initiation and progression. PURPL (p53-upregulated regulator of p53 levels) is an emerging oncogenic lncRNA that plays a pivotal role in modulating multiple cancer-related cellular pathways, including the p53 signaling pathway, autophagy, miRNA-mediated gene regulation, genome stability, cellular senescence, and metastasis. Mechanistically, PURPL orchestrates signaling networks and epigenetic regulation via diverse molecular modes, functioning as a competing endogenous RNA (ceRNA), molecular scaffold, and guide, thereby influencing gene expression and cellular homeostasis. Functional studies reveal that suppression of PURPL enhances chemosensitivity, inhibits tumor cell proliferation and migration, and induces apoptosis across multiple cancer types. This review systematically summarizes the molecular mechanisms underlying PURPL-mediated regulation and highlights its multifaceted roles in cancer biology, thereby providing an integrative view of its functions in tumorigenesis and cellular regulation.

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长链非编码RNA PURPL在癌症和细胞调控中的作用：机制见解和治疗潜力。

长链非编码rna （lncRNAs）构成了哺乳动物转录组的很大一部分，并且越来越被认为是基因表达和细胞稳态的关键调节因子。lncrna的失调与癌症的发生和发展密切相关。PURPL是一种新兴的致癌lncRNA，在多种癌症相关的细胞通路中起关键作用，包括p53信号通路、自噬、mirna介导的基因调控、基因组稳定、细胞衰老和转移。从机制上讲，PURPL通过多种分子模式协调信号网络和表观遗传调控，作为竞争的内源性RNA （ceRNA）、分子支架和向导，从而影响基因表达和细胞稳态。功能研究表明，在多种肿瘤类型中，抑制PURPL可增强化疗敏感性，抑制肿瘤细胞增殖和迁移，诱导细胞凋亡。本文系统总结了purpl介导调控的分子机制，并强调了其在癌症生物学中的多方面作用，从而提供了其在肿瘤发生和细胞调控中的综合功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioimpacts Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.80

自引率

7.70%

发文量

审稿时长

5 weeks

期刊介绍： BioImpacts (BI) is a peer-reviewed multidisciplinary international journal, covering original research articles, reviews, commentaries, hypotheses, methodologies, and visions/reflections dealing with all aspects of biological and biomedical researches at molecular, cellular, functional and translational dimensions.