Impact of pupil dilation on IOL power calculation based on biometric measurements with Heidelberg Anterion.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Documenta Ophthalmologica Pub Date : 2026-06-12 DOI:10.1007/s10633-026-10117-7

Sara Marquina-Martín, Francisco J Segura-Calvo, Martín Puzo-Bayod, Marta Jiménez-García, Francisco J Castro-Alonso

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引用次数: 0

Abstract

Purpose: To evaluate the impact of pharmacologic pupil dilation (PD) on biometric measurements and intraocular lens (IOL) power calculation using different generation formulas in patients undergoing cataract surgery.

Methods: This prospective study included 126 eyes from 75 patients. Biometric data were obtained before and after pharmacologic dilation using the Anterion Swept-Source OCT biometer (Heidelberg Engineering). Parameters recorded included axial length (AL), mean keratometry (Km), anterior chamber depth (ACD), lens thickness (LT), and white-to-white (WTW) distance. IOL power was calculated using six formulas: SRK/T, Haigis, Barrett Universal II (BUII), Kane, Hoffer QST, and Okulix. Statistical comparisons of biometric values and predicted IOL power before and after dilation were conducted using mixed-effects models.

Results: No significant changes were observed in AL, CCT, LT or Km after dilation. However, ACD, WTW distance and PD showed statistically significant increases (both p < 0.01). IOL power estimations based on SRK/T, Haigis, Hoffer QST, BUII and Kane were not significantly affected after dilation. In contrast, Okulix formulas demonstrated statistically significant variations in calculated IOL power post-dilation (p < 0.0001).

Conclusions: Pharmacologic pupil dilation induces changes in ACD and WTW measurements obtained using the Anterion Swept-Source biometer, thereby influencing IOL power estimation in formulas incorporating these parameters. Ray-tracing Okulix formula is more sensitive to dilation, whereas third-generation formulas remain more stable. Consistency in pupil status during biometry acquisition is essential to ensure refractive predictability.

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瞳孔扩张对基于Heidelberg Anterion生物特征测量的IOL度数计算的影响。

目的：评价不同生成公式下药理学瞳孔扩张（PD）对白内障手术患者生物特征测量和人工晶状体（IOL）度数计算的影响。方法：本前瞻性研究纳入75例患者126只眼。使用Anterion扫描源OCT生物计（Heidelberg Engineering）获得药物扩张前后的生物特征数据。记录的参数包括轴长（AL）、平均角膜度数（Km）、前房深度（ACD）、晶状体厚度（LT）和白到白（WTW）距离。采用SRK/T、Haigis、Barrett Universal II （BUII）、Kane、Hoffer QST和Okulix六个公式计算人工晶体度数。采用混合效应模型对人工晶状体扩张前后的生物特征值和预测晶状体度数进行统计比较。结果：扩张后AL、CCT、LT、Km均无明显变化。然而，ACD、WTW距离和PD均有统计学意义的增加（均为p）。结论：药理学瞳孔扩张导致使用Anterion扫描源生物计获得的ACD和WTW测量值的变化，从而影响了包含这些参数的公式中的IOL功率估计。射线追踪Okulix公式对膨胀更敏感，而第三代公式保持更稳定。一致性的瞳孔状态在生物测量采集是必不可少的，以确保屈光预测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).