Azra Ramezankhani, Amir Abdi, Parto Hadaegh, Farzad Hadaegh
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引用次数: 0
Abstract
Background: We investigated the associations of dietary and lifestyle inflammation scores (DIS and LIS) with the incidence of all cardiovascular disease (CVD) events, its different subtypes, including hard CVD, stroke, myocardial infarction (MI), as well as heart failure (HF).
Methods: We analyzed data from 5866 participants aged ≥ 45 years from the Multi-Ethnic Study of Atherosclerosis (MESA). DIS and LIS were constructed using food frequency and lifestyle questionnaire data. Multivariable Cox regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of DIS and LIS for CVD outcomes.
Results: Over 14 years, there were 822, 600, 290, 252, and 270 events of all CVD, hard CVD, HF, stroke, and MI, respectively. In continuous scale, each one-point increase in DIS was associated with higher risk of all CVD (HR: 1.03; 95% CI: 1.01-1.07), hard CVD (1.05; 1.01-1.08), and MI (1.06; 1.01-1.12). In quintile analysis, the highest DIS quintile was associated with an elevated risk of all CVD (1.28; 1.02-1.61; P trend = 0.067) and hard CVD events (1.47; 1.12-1.92; P trend = 0.013). In subgroup analysis, the impact of DIS on all CVD events was more pronounced among overweight participants compared to normal weight or obese counterparts (P-interaction < 0.001). Furthermore, each one-point increase in LIS was associated with a 36% higher risk of HF (1.36; 1.12-1.62). Participants in the highest LIS quintile had a 75% higher risk of HF (1.75: 1.18-2.59), compared to those in the lowest quintile.
Conclusion: Diet and lifestyle, through their contributions to inflammation, may be associated with higher CVD risk, particularly hard CVD, MI, and HF.
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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