Nanomedicine-Based Approaches for Therapeutic Delivery Across the Blood-Brain Barrier in Neurological Disorders.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2026-04-28 DOI:10.2174/0113816128412258251127103243

Anuj Garg, Khusboo Lavania, Rabinarayan Parhi, Gireesh Kumar Singh, Javed Ahmad, Ankit Jain

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Abstract

Therapeutic delivery to the Central Nervous System (CNS) is challenging for formulation scientists due to the transfer of therapeutics across the Blood-Brain Barrier (BBB). The BBB consists of a selective semi-permeable anatomical structure of the capillary basement membrane, capillary endothelial cells, pericytes, and astrocytes. It restricts the drug transfer from the blood compartment to the brain tissues. Therefore, the desirable effects of various therapeutics in different CNS disorders (like Alzheimer's disease, schizophrenia, Parkinson's disease, etc.) require the transfer of drugs across the BBB. Hence, various approaches have been explored for deeper penetration of CNS-acting drugs across the BBB. Among various formulation approaches, Drug Delivery Systems (DDS) utilizing colloidal carrier systems are one of the most promising strategies to overcome BBB limitations and achieve brain targeting in different CNS disorders. This review provides a comprehensive discussion of drug delivery challenges across the BBB and technology advancements utilized to achieve improved therapeutic efficacy in different CNS disorders.

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基于纳米医学的神经系统疾病血脑屏障治疗递送方法。

由于药物通过血脑屏障（BBB）转移，将治疗药物输送到中枢神经系统（CNS）对配方科学家来说是一个挑战。血脑屏障由毛细血管基底膜、毛细血管内皮细胞、周细胞和星形胶质细胞的选择性半透解剖结构组成。它限制了药物从血液室向脑组织的转移。因此，在不同的中枢神经系统疾病（如阿尔茨海默病、精神分裂症、帕金森病等）中，各种治疗方法的理想效果需要通过血脑屏障转移药物。因此，研究人员探索了多种方法，以使中枢神经系统作用的药物更深入地渗透到血脑屏障中。在各种制剂方法中，利用胶体载体系统的药物递送系统（DDS）是克服血脑屏障限制并实现不同中枢神经系统疾病脑靶向治疗的最有前途的策略之一。这篇综述全面讨论了跨血脑屏障的药物传递挑战以及用于提高不同中枢神经系统疾病治疗效果的技术进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.