Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study.

IF 4.2 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI:10.1002/mnfr.70465

Joana Llauradó-Pont,Sofia Aguilar-Lacasaña,Marta Cosin-Tomas,Jordi Julvez,Oren Contreras-Rodríguez,Manolis Kogevinas,Kyriaki Papantoniou,Elisa Gallo,Barbara N Harding,Martine Vrijheid,Payam Dadvand,Mariona Bustamante,Camille Lassale

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引用次数: 0

Abstract

The impact of diet during pregnancy on birth outcomes and child health is well established, and epigenetic changes may be one mechanism underlying such associations, but the role of meal timing (chrono-nutrition) is unclear. We conducted an epigenome-wide association study (EWAS) of maternal meal timing and placental DNAm (plaDNAm). Data came from 389 pregnant women in the Barcelona Life Study Cohort (BiSC). Chrono-nutrition and dietary data were collected at 20 weeks of pregnancy, and plaDNAm at delivery was characterized using the Illumina EPIC array. Linear robust regression models tested associations between five chrono-nutritional behaviors (time of first and last meal, nighttime fasting duration, number of eating occasions, and eating jetlag) and plaDNAm. We identified 7 CpGs significantly associated with time of last meal (Bonferroni p < 1E-08) and 63 suggestive CpGs (p < 1E-05). Hits included cg13147785 (E2F8), linked to placental cell cycle regulation, cg17665505 (DAP) and cg18303215 (ABCG5), associated with smoking and lung diseases in adults. To conclude, maternal chrono-nutrition was associated with some CpGs in the placenta, particularly time of last meal. Further studies are needed to clarify how meal timing may influence fetal development and long-term health through epigenetic mechanisms.

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母体时间营养和胎盘DNA甲基化：BiSC研究。

怀孕期间饮食对出生结果和儿童健康的影响已经得到证实，表观遗传变化可能是这种关联背后的一种机制，但进餐时间（时间营养）的作用尚不清楚。我们进行了一项母体进餐时间与胎盘dna （plaDNAm）的全表观基因组关联研究（EWAS）。数据来自巴塞罗那生命研究队列（BiSC）的389名孕妇。在怀孕20周时收集时间营养和饮食数据，并使用Illumina EPIC阵列对分娩时的plaDNAm进行表征。线性稳健回归模型测试了五种时间营养行为（第一餐和最后一餐的时间、夜间禁食持续时间、进食次数和进食时差）与plaDNAm之间的关系。我们发现了7个与最后一餐时间显著相关的CpGs （Bonferroni p < 1E-08）和63个提示CpGs （p < 1E-05）。Hits包括cg13147785 (E2F8)，与胎盘细胞周期调节相关，cg17665505 （DAP）和cg18303215 (ABCG5)，与成人吸烟和肺部疾病相关。综上所述，母体时间营养与胎盘中的一些CpGs有关，特别是最后一餐时间。需要进一步的研究来阐明进餐时间如何通过表观遗传机制影响胎儿发育和长期健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.